Delayed administration of memantine prevents N‐methyl‐D‐aspartate receptor‐mediated neurotoxicity
Pellegrini J, Lipton S. Delayed administration of memantine prevents N‐methyl‐D‐aspartate receptor‐mediated neurotoxicity. Annals Of Neurology 1993, 33: 403-407. PMID: 8098195, DOI: 10.1002/ana.410330414.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsN-methyl-D-aspartate receptor-mediated neurotoxicityPotent N-methyl-D-aspartate antagonistNeonatal rat retinal ganglion cellsN-methyl-D-aspartate (NMDA) subtypeN-methyl-D-aspartate antagonistsRat retinal ganglion cellsImmunodeficiency syndrome (AIDS) dementiaAcute neurological conditionsHypoxia/ischemiaChronic neurodegenerative diseasesRetinal ganglion cellsNeuronal cell deathMicroM memantineAntiparkinsonian drugsCentral neuronsGanglion cellsExcessive activationGlutamate receptorsNeurological conditionsNeurodegenerative diseasesHuntington's diseaseNeurotoxicityPrimary culturesDisease