1994
Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca2+-mediated injury in myelinated CNS axons
Waxman S, Black J, Ransom B, Stys P. Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca2+-mediated injury in myelinated CNS axons. Brain Research 1994, 644: 197-204. PMID: 8050031, DOI: 10.1016/0006-8993(94)91680-2.Peer-Reviewed Original ResearchConceptsOptic nerveOptic nerve axonsRat optic nerveNerve axonsBrain slice chamberCompound action potentialLoss of cristaeMicroM tetrodotoxinAnoxic injuryNormoxic controlsNerveAstrocyte processesPerinodal astrocyte processesWhite matterMyelinated axonsAstrocytic processesCNS axonsTetrodotoxinAction potentialsSlice chamberAxonsLoss of microtubulesCytoskeletal damageInjuryNormoxic conditions
1993
Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium
Waxman S, Black J, Ransom B, Stys P. Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium. Brain Research 1993, 614: 137-145. PMID: 8348309, DOI: 10.1016/0006-8993(93)91027-p.Peer-Reviewed Original ResearchConceptsArtificial cerebrospinal fluidMin of anoxiaOptic nerveZero-Ca2White matterAnoxic injuryCNS white matter tractAxonal cytoskeletonOptic nerve axonsCNS white matterRat optic nerveInflux of Ca2White matter tractsLoss of cristaeDisorganization of cristaeMembranous profilesUltrastructure of axonsAbnormal influxCerebrospinal fluidExtracellular calciumNerveMyelinated axonsNerve axonsNormal Ca2Axons
1992
Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve
Waxman S, Black J, Stys P, Ransom B. Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve. Brain Research 1992, 574: 105-119. PMID: 1638387, DOI: 10.1016/0006-8993(92)90806-k.Peer-Reviewed Original ResearchConceptsOptic nerveRat optic nerveMin of anoxiaPost-anoxic recoveryAnoxic injuryAstrocyte processesMyelin sheathLoss of microtubulesCell-mediated damageCNS white matterInflux of calciumLarge-diameter axonsPrevious electrophysiological studiesAction potential conductionWhite matter tractsNodes of RanvierAnoxic insultUltrastructure of axonsGlial cellsVesicular degenerationConduction blockEarly recoveryElectrophysiological studiesNerveSignificant injury
1990
Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia
Stys P, Ransom B, Waxman S. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neuroscience Letters 1990, 115: 293-299. PMID: 2234507, DOI: 10.1016/0304-3940(90)90471-k.Peer-Reviewed Original ResearchConceptsAnoxic injuryChannel blockersWhite matterMammalian central white matterDihydropyridine calcium channel blockerChannel blockers Mn2Irreversible anoxic injuryCalcium channel blockersCNS white matterCompound action potentialCentral white matterDihydropyridine classOrganic Ca2Inorganic Ca2Extracellular Ca2Action potentialsNerve modelMin periodBlockersInjuryFunctional integrityConventional Ca2Ca2InfluxIntracellular compartments