2023
Voltage-gated sodium channels (Na<sub>V</sub>) in GtoPdb v.2023.1
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f82/2023.1.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresVoltage-gated sodium channelsShort selectivity filterSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIon channelsSubunitsPore region
2021
Voltage-gated sodium channels (Na<sub>V</sub>) in GtoPdb v.2021.3
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f82/2021.3.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresVoltage-gated sodium channelsShort selectivity filterSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIon channelsSubunitsPore region
2019
Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f82/2019.4.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresShort selectivity filterVoltage-gated sodium channelsSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIUPHAR/BPS GuideIon channelsSubunitsSodium Channels and Pain
Cummins T, Waxman S, Wood J. Sodium Channels and Pain. 2019, 233-262. DOI: 10.1093/oxfordhb/9780190860509.013.3.Peer-Reviewed Original ResearchSodium channel blockersPain conditionsChannel blockersSodium channelsAnalgesic drug targetsDifferent pain statesFunction Nav1.7 mutationsMost pain conditionsPeripheral sodium channelsSodium channel subtypesDamage-sensing neuronsDrug developmentVoltage-gated sodium channelsSodium channel isoformsDrug development programsIon channelsExcellent analgesicPain controlPain reliefPain statesNav1.7 mutationSodium-selective ion channelsNew analgesicsLocal anestheticsTherapeutic approaches