2005
29 Blocking the Axonal Injury Cascade Neuroprotection in Multiple Sclerosis and Its Models
Waxman S, Lo A. 29 Blocking the Axonal Injury Cascade Neuroprotection in Multiple Sclerosis and Its Models. 2005, 435-449. DOI: 10.1016/b978-012738761-1/50030-4.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisWhite matter injuryAxonal injuryChannel blockersNitric oxideNon-glucocorticoid steroidsCalcium channel blockersHuman multiple sclerosis lesionsSodium channel blockersMultiple sclerosis lesionsEffects of drugsAutoimmune encephalomyelitisMS pathologyOptic nerveMultiple sclerosisFunctional outcomeNeuroprotective agentsΓ-aminobutyric acidHypoxic injuryPathological evidenceSpinal nervesSpinal cordAdrenergic receptorsVivo preparationSclerosis lesions
1992
Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter
Stys P, Waxman S, Ransom B. Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 977-986. PMID: 1400652, DOI: 10.1038/jcbfm.1992.135.Peer-Reviewed Original ResearchConceptsFunctional recoveryWhite matterAnoxic injuryMin of anoxiaOptic nerveFunctional outcomeTypical CNS white matter tractAnoxic exposureIntracellular Ca2Anoxic/ischemic injuryCNS white matter tractCompound action potential areaGray matterIsolated rat optic nerveGreater functional recoveryEvoked electrical activityAction potential areaCNS white matterRat optic nerveWhite matter tractsFunctional injuryIschemic injuryPathological increaseAnoxic damageCAP peak