1998
Effects of Glucose Deprivation, Chemical Hypoxia, and Simulated Ischemia on Na+ Homeostasis in Rat Spinal Cord Astrocytes
Rose C, Waxman S, Ransom B. Effects of Glucose Deprivation, Chemical Hypoxia, and Simulated Ischemia on Na+ Homeostasis in Rat Spinal Cord Astrocytes. Journal Of Neuroscience 1998, 18: 3554-3562. PMID: 9570787, PMCID: PMC6793162, DOI: 10.1523/jneurosci.18-10-03554.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntimetabolitesAstrocytesBenzofuransCell HypoxiaDeoxyglucoseEnergy MetabolismEnzyme InhibitorsEthers, CyclicExcitatory Amino Acid AgonistsFluorescent DyesFluorides, TopicalGlucoseGlycolysisHomeostasisIschemiaKainic AcidNeurotoxinsOuabainRatsRats, Sprague-DawleySodiumSodium AzideSodium FluorideSodium-Potassium-Exchanging ATPaseSpinal CordTetrodotoxinConceptsSpinal cord astrocytesChemical hypoxiaGlucose deprivationEnergy failureCultured spinal cord astrocytesGlutamatergic agonist kainateGlucose salineGlutamate reuptakeVivo ischemiaSpinal cordGlial functionMetabolic insultsSimulated ischemiaAgonist kainateIschemiaStandard salineAstrocytesSalineHypoxiaIntracellular ion concentrationsGlucose removalExtracellular spaceDeprivationL-lactateReperfusion
1996
Voltage-gated Na+ channels in glia: properties and possible functions
Sontheimer H, Black J, Waxman S. Voltage-gated Na+ channels in glia: properties and possible functions. Trends In Neurosciences 1996, 19: 325-331. PMID: 8843601, DOI: 10.1016/0166-2236(96)10039-4.Peer-Reviewed Original ResearchWhite Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications
Fern R, Ransom B, Waxman S. White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications. Cerebrovascular Diseases 1996, 6: 59-65. DOI: 10.1159/000107999.Peer-Reviewed Original ResearchWhite matterAnoxic injuryWhite matter strokeIncidence of strokeCNS white matterLevels of GABARecovery of functionResult of anoxiaIrreversible dysfunctionAnoxic insultPharmacological strategiesIrreversible injuryTherapeutic implicationsEndogenous storesExogenous GABAInjuryGABAAutoprotective mechanismsStrokeIntracellular eventsExtracellular spaceCa2Protective treatmentAdenosineInflux
1994
Astrocyte Na+ channels are required for maintenance of Na+/K(+)-ATPase activity
Sontheimer H, Fernandez-Marques E, Ullrich N, Pappas C, Waxman S. Astrocyte Na+ channels are required for maintenance of Na+/K(+)-ATPase activity. Journal Of Neuroscience 1994, 14: 2464-2475. PMID: 8182422, PMCID: PMC6577452, DOI: 10.1523/jneurosci.14-05-02464.1994.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesAstrocytomaCell LineCells, CulturedElectrophysiologyGanglia, SpinalGliomaMembrane PotentialsModels, BiologicalOuabainRatsRats, Sprague-DawleyRubidiumSodiumSodium ChannelsSodium-Potassium-Exchanging ATPaseStrophanthidinTetrodotoxinTime FactorsTumor Cells, CulturedConceptsEffects of TTXGlial cellsAction potential electrogenesisRat spinal cordPatch-clamp recordingsAstrocyte membrane potentialDose-dependent mannerVoltage-activated channelsAcute blockadeSpinal cordVoltage-activated ion channelsSpecific blockerATPase activityAstrocytesTTXAstrocyte deathAction potentialsUnidirectional influxBlockadeExcitable cellsIon channelsOuabainExtracellular spaceMembrane potentialIon levels
1985
Rat optic nerve: Disruption of gliogenesis with 5-azacytidine during early postnatal development
Ransom B, Yamate C, Black J, Waxman S. Rat optic nerve: Disruption of gliogenesis with 5-azacytidine during early postnatal development. Brain Research 1985, 337: 41-49. PMID: 2408709, DOI: 10.1016/0006-8993(85)91607-5.Peer-Reviewed Original ResearchConceptsOptic nerveGlial cellsOptic nerve axonsRat optic nerveCompound action potentialEarly postnatal developmentDays of ageOlder nervesNeonatal treatmentBrain extracellular spaceNeuroglial interactionsElectrophysiological studiesNervePostnatal developmentAction potentialsNerve axonsExcitability propertiesMarked reductionMyelin formationGliogenesisMitotic inhibitorsIonic homeostasisExtracellular spaceAgeAnimals
1983
Fine structure of regenerated ependyma and spinal cord in Sternarchus albifrons
Anderson M, Waxman S, Laufer M. Fine structure of regenerated ependyma and spinal cord in Sternarchus albifrons. The Anatomical Record 1983, 205: 73-83. PMID: 6837937, DOI: 10.1002/ar.1092050110.Peer-Reviewed Original ResearchConceptsDense-core vesiclesEpendymal cellsRegenerated cordSpinal cordCell bodiesNumerous dense-cored vesiclesSternarchus albifronsNormal cordCentral canalFibrous astrocytesMyelinated axonsCordElectromotor neuronsEpendymal layerVentral portionRegenerated spinal cordMeningeal layersNeuritesBasal laminaExtracellular spaceAdditional cellsCellsCell processesCell cytoplasmEpendymal tube