1985
A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates.
Strittmatter SM, Thiele EA, Kapiloff MS, Snyder SH. A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. Journal Of Biological Chemistry 1985, 260: 9825-9832. PMID: 2991265, DOI: 10.1016/s0021-9258(17)39310-9.Peer-Reviewed Original ResearchConceptsBrain ACESubstance PLung ACERat brain corpus striatumSubstance KMet-NH2Substance P 5Hormone-releasing hormoneLung enzymeThyrotropin-releasing hormoneAngiotensin-converting enzymeSubstance P 1Striatonigral pathwayCorpus striatumRat lungAmidated peptidesLungStriatal enzymeACE isozymeGly-LeuBrain enzymeBrain isozymeSimilar extentImmunological propertiesACESubstance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain
Thiele E, Strittmatter S, Snyder S. Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain. Biochemical And Biophysical Research Communications 1985, 128: 317-324. PMID: 2580530, DOI: 10.1016/0006-291x(85)91681-x.Peer-Reviewed Original Research
1984
Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.
Strittmatter SM, Lo MM, Javitch JA, Snyder SH. Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1599-1603. PMID: 6324207, PMCID: PMC344885, DOI: 10.1073/pnas.81.5.1599.Peer-Reviewed Original ResearchConceptsCaudate putamenSubstantia nigraStriatonigral pathwayRat brainAngiotensin II involvementIpsilateral caudate putamenTrans-synaptic changesIpsilateral substantia nigraMedian preoptic areaAngiotensin-converting enzymeLack of effectStriatal interneuronsAngiotensin IIEntopeduncular nucleusNeuronal perikaryaSubfornical organZona reticulataGlobus pallidusACE activityLocus coeruleusParaventricular nucleusPreoptic areaIbotenic acidMedial habenulaNeuronal pathways