Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
Harel NY, Strittmatter SM. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nature Reviews Neuroscience 2006, 7: 603-616. PMID: 16858389, PMCID: PMC2288666, DOI: 10.1038/nrn1957.Peer-Reviewed Original ResearchConceptsCNS regenerationNervous systemCentral pattern generatorImmature nervous systemSpinal cord injuryRegeneration-associated genesMammalian CNS regenerationContext of injuryExperience-dependent plasticityFurther plastic changesInflammatory cellsCord injuryVoluntary inputNervous system developmentRegenerating axonsSensory feedbackInhibitory barrierPlastic changesInhibitory moleculesRegenerative responseGuidance moleculesAltered distributionNeuronal branchesInjuryGuidance factors