2018
Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration
Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Reports 2018, 23: 415-428. PMID: 29642001, PMCID: PMC5937716, DOI: 10.1016/j.celrep.2018.03.058.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsCentral Nervous SystemFemaleGene Regulatory NetworksGenomeMiceMice, Inbred C57BLMice, KnockoutNerve RegenerationOptic NerveRab GTP-Binding ProteinsRecovery of FunctionRetinal Ganglion CellsRNA InterferenceRNA, Small InterferingSpinal Cord InjuriesSuppressor of Cytokine Signaling ProteinsConceptsAxonal regenerationCentral nervous system axonal regenerationRetinal ganglion cell axon regenerationGreater motor functionOptic nerve crushCerebral cortical neuronsSpinal cord traumaNeurological recoveryCord traumaNerve crushCNS injuryAxonal regrowthCortical neuronsMotor functionAxon regenerationReceptor bindingComprehensive functional screenAdult mammalsInjuryMultiple pathwaysExpression profilesIdentifies pathwaysSignificant overlapPathwayFunction screen
2003
Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth
Tanabe K, Bonilla I, Winkles JA, Strittmatter SM. Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth. Journal Of Neuroscience 2003, 23: 9675-9686. PMID: 14573547, PMCID: PMC6740475, DOI: 10.1523/jneurosci.23-29-09675.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxotomyGanglia, SpinalGene Expression ProfilingGene Expression RegulationHumansMaleMembrane ProteinsMiceMice, Inbred C57BLNerve RegenerationNeuritesNeuronsOligonucleotide Array Sequence AnalysisPC12 CellsPseudopodiaRac1 GTP-Binding ProteinRatsReceptors, Tumor Necrosis FactorRNA, MessengerSciatic NeuropathyTWEAK ReceptorConceptsFibroblast Growth Factor-Inducible 14Dorsal root gangliaDozens of genesDRG neuronsRho family GTPasesPC12 cellsGene expression patternsNeurite outgrowthAxotomized neuronsMRNA expression profilesPromotes Neurite OutgrowthNerve growth factor treatmentRac1 inactivationRac1 GTPaseExpression patternsExpression profilesMicroarray analysisAxotomized DRG neuronsOverexpression of Fn14Rac1 activationNorthern analysisSciatic nerve injurySciatic nerve transectionCoordinated shiftImmunoprecipitation studies