2024
Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage
Willms J, Boss J, Huo S, Wolf S, Westphal L, Bögli S, Inauen C, Baumann D, Fröhlich J, Keller E. Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage. Journal Of Neuroscience Methods 2024, 406: 110113. PMID: 38537749, DOI: 10.1016/j.jneumeth.2024.110113.Peer-Reviewed Original ResearchDetection of delayed cerebral ischemiaAneurysmal subarachnoid hemorrhagePoor-grade aneurysmal subarachnoid hemorrhagePerfusion deficitsSubarachnoid hemorrhageIntracranial pressureCerebral ischemiaMedian valuePerfusion CT scansCerebral perfusion deficitsDetect perfusion deficitsBrain tissue oxygen pressureMeasurement of intracranial pressureCT scanTissue oxygen pressureComatose patientsCerebral infarctionPatientsNear-infrared spectroscopyMultimodal neuromonitoringPatient collectivesHbtotalPerfusionInfarctionPbtO2
2019
Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Major S, Huo S, Lemale C, Siebert E, Milakara D, Woitzik J, Gertz K, Dreier J. Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. GeroScience 2019, 42: 57-80. PMID: 31820363, PMCID: PMC7031471, DOI: 10.1007/s11357-019-00142-7.Peer-Reviewed Original ResearchConceptsDepression of activityDirect electrophysiological evidenceMigraine auraNeurological deficitsPathophysiological correlatesGray matterMassive glutamate releaseMassive ion translocationTransient ischemic attackFocal neurological deficitsCerebral amyloid angiopathyAneurysmal subarachnoid hemorrhageElectrophysiological evidenceMass injuryBrain gray matterIschemic attackMigraine strokeDendritic beadingAmyloid angiopathyGlutamate releaseSubarachnoid hemorrhageDirect current potentialNeuronal somataClinical distinctionIschemic tissue