2021
Neuropathogenesis of acute coronavirus disease 2019
Farhadian SF, Seilhean D, Spudich S. Neuropathogenesis of acute coronavirus disease 2019. Current Opinion In Neurology 2021, 34: 417-422. PMID: 33852526, DOI: 10.1097/wco.0000000000000944.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute SARS-CoV-2 infectionSARS-CoV-2 infectionNeurological complicationsSevere acute respiratory syndrome coronavirus 2Acute coronavirus disease 2019Acute respiratory syndrome coronavirus 2Potential long-term complicationsCOVID-19Respiratory syndrome coronavirus 2Direct viral invasionImmune-modulating interventionsCentral nervous system tissueLong-term complicationsSpecific immune responseSyndrome coronavirus 2Coronavirus disease 2019Nervous system tissueSubset of casesCoronavirus disease (COVID-19) pandemicParainfectious processViral meningoencephalitisNeurological symptomsVascular inflammationEndothelial activationCoronavirus 2
2020
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.Peer-Reviewed Original ResearchConceptsInitial presentationCentral nervous system inflammationSARS-CoV-2 infectionCSF inflammatory markersNervous system inflammationCerebrospinal fluid (CSF) cytokinesSeizure-like activityCOVID-19 infectionVirus SARS-CoV-2COVID-19SARS-CoV-2BackgroundCOVID-19Inflammatory markersNeurologic complicationsSystem inflammationImmunocompromised womanNeurologic manifestationsNeurologic symptomsViral neuroinvasionCase presentationWeInfected patientsMental statusRespiratory pathogensConclusionOur findingsInflammation