2017
Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy
Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S. Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy. The Journal Of Infectious Diseases 2017, 215: 1132-1140. PMID: 28368497, PMCID: PMC5426376, DOI: 10.1093/infdis/jix013.Peer-Reviewed Original ResearchConceptsPrimary HIV infectionCombination antiretroviral therapyHIV infectionNeurofilament light chainAntiretroviral therapyCreatinine levelsCerebrospinal fluidN-acetylaspartateAbnormal blood-brain barrier (BBB) permeabilityPrimary human immunodeficiency virus (HIV) infectionBlood-brain barrier disruptionHuman immunodeficiency virus (HIV) infectionBlood-brain barrier permeabilityNeuropsychological performanceImmunodeficiency virus infectionParietal gray matterYears of treatmentLongitudinal observational studyCART durationCART initiationMedian intervalNeuronal injuryAlbumin quotientNfL levelsCSF levels
2014
Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection
Young AC, Yiannoutsos CT, Hegde M, Lee E, Peterson J, Walter R, Price RW, Meyerhoff DJ, Spudich S. Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection. Neurology 2014, 83: 1592-1600. PMID: 25261502, PMCID: PMC4223087, DOI: 10.1212/wnl.0000000000000932.Peer-Reviewed Original ResearchConceptsPrimary HIV infectionParietal gray matterInitiation of ARTMI/CrFrontal white matterAntiretroviral therapyGlu/CrCho/CrHIV infectionBasal gangliaWhite matterGray matterN-acetylaspartateT proton magnetic resonance spectroscopyCerebral metabolite changesEarly ART initiationTreatment-naive participantsEarly antiretroviral therapyLevels of glutamateNAA/CrProton magnetic resonance spectroscopyCholine-containing metabolitesMagnetic resonance spectroscopyART initiationHigh-field magnetic resonance spectroscopy