2024
Interventional Brain Medicine: Medicine's newest frontier
Nuthalapati P, Palmer C, Barbosa D, George M, Brown J. Interventional Brain Medicine: Medicine's newest frontier. 2024, 1-3. DOI: 10.61373/bm024g.0013.Peer-Reviewed Original ResearchEx Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2
Singh H, Nuthalapati P, Yendapalli P, Sahu D. Ex Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2. 2024, 258-271. DOI: 10.1039/bk9781837672813-00258.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsNatural killer cellsCell-mediated immunityBlood mononuclear cellsEnhanced immune responseNaive lymphocytesDendritic cellsKiller cellsT cellsAntigen presentationB cellsMononuclear cellsImmune responseSARS-nCoV-2Human hostSignaling cascadesSARS-CoV-2Global pandemic coronavirus diseaseVirion particlesImmunityMass immunizationAdverse effectsCoronavirus 2Pandemic coronavirus diseaseNeuroinvasion by SARS-CoV-2 Influences the Prognosis of Neurological Disorders
Nuthalapati P, Ghanta M, Farran B, Chenchula S, Vedam V, Pukalendiran V, Amerneni K, Bhaskar L. Neuroinvasion by SARS-CoV-2 Influences the Prognosis of Neurological Disorders. 2024, 272-308. DOI: 10.1039/bk9781837672813-00272.Peer-Reviewed Original ResearchMultifaceted Study of a Y‑Shaped Pyrimidine Compound: Assessing Structural Properties, Docking Interactions, and Third-Order Nonlinear Optics
Potla K, Nuthalapati P, Mohan J, Osório F, Valverde C, Vankayalapati S, Adimule S, Armaković S, Armaković S, Mary Y. Multifaceted Study of a Y‑Shaped Pyrimidine Compound: Assessing Structural Properties, Docking Interactions, and Third-Order Nonlinear Optics. ACS Omega 2024, 9: 7424-7438. PMID: 38405509, PMCID: PMC10882687, DOI: 10.1021/acsomega.3c04380.Peer-Reviewed Original ResearchNonlinear optical propertiesReactivity descriptorsDocking studiesMolecular dynamicsThird-order nonlinear opticsLocal reactivity propertiesPeriodic DFT calculationsOptical propertiesNonlinear optical materialsMolecular docking studiesX-ray diffractionThird-order nonlinear susceptibilityNonlinear susceptibilityDFT calculationsFourier transform infraredNuclear magnetic resonance techniquesNoncovalent interactionsWater moleculesSpectroscopic characterizationReactivity parametersCrystal structureMD simulationsStructural characterizationOptical materialsThermal analysis
2023
Improving Seizure Frequency Documentation and Classification.
Nuthalapati P, Thomas L, Donahue M, Moura L, DeStefano S, Simpson J, Buchhalter J, Fureman B, Pellinen J. Improving Seizure Frequency Documentation and Classification. Neurology Clinical Practice 2023, 13: e200212. PMID: 37873534, PMCID: PMC10586801, DOI: 10.1212/cpj.0000000000200212.Peer-Reviewed Original ResearchElectronic health recordsEpilepsy Learning Healthcare SystemClinic visitsLearning healthcare systemQuality of careBaseline dataQuality improvement projectBaseline data collectionEpilepsy clinicHealth recordsCase report formsDocumentation habitsImprovement projectHealthcare systemDocumentation toolsReport formsVisitsEvaluate treatment strategiesClinicData collectionSeizure documentationBaselineSeizure frequencyCritical metricsCareFeasibility and Insights from Automated Depression and Anxiety Screening for People with Epilepsy (P1-1.004)
Coelho L, Donahue M, Sevak Y, Nuthalapati P, Buchhalter J, Fureman B, Herman S, Moura L. Feasibility and Insights from Automated Depression and Anxiety Screening for People with Epilepsy (P1-1.004). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202283.Peer-Reviewed Original Research
2022
Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial
Vedam V, Ghanta M, Kantipudi S, David D, Vijayalakshmi M, Nuthalapati P. Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial. Journal Of Pharmacology And Pharmacotherapeutics 2022, 13: 284-292. DOI: 10.1177/0976500x221128649.Peer-Reviewed Original ResearchBrief Psychiatric Rating ScaleBrief Psychiatric Rating Scale scoresSchizophrenia patientsAbnormal Involuntary Movement Scale scorePsychiatric Rating ScaleEfficacy of olanzapineSafety of haloperidolHomocysteine levelsOlanzapine groupHaloperidol groupSchizophrenia treatmentPeripheral bloodOlanzapineRating ScalePilot randomized controlled trialHaloperidolSchizophreniaLevels of peripheral bloodTreatment outcomesScale scoreInterventional clinical trialsBlood homocysteine levelsRandomized controlled trialsClinical outcomesRight drugAn Outbreak of Oxidative Stress in Pathogenesis of Alzheimer's Disease
Garg S, Nuthalapati P, Devi S, Sharma A, Sahu D, Gupta J. An Outbreak of Oxidative Stress in Pathogenesis of Alzheimer's Disease. 2022, 201-208. DOI: 10.1201/9781003157823-16.Peer-Reviewed Original ResearchAmyloid-bFormation of senile plaquesPathogenesis of Alzheimer's diseaseIntracellular neurofibrillary tanglesAmyloid-b peptideAlzheimer's diseaseNeurofibrillary tanglesOxidative stressSenile plaquesReactive oxygen speciesOxidative damageHallmarks of diseaseOxygen speciesNeurodegenerative ailmentsRedox-active metal ionsMetal ionsPathogenesisTanglesProteinSpeciesNanoparticles: The Promising Future of Advanced Diagnosis and Treatment of Neurological Disorders
Nuthalapati P, Asaithambi S, Kumar M, Reddy D. Nanoparticles: The Promising Future of Advanced Diagnosis and Treatment of Neurological Disorders. 2022, 221-234. DOI: 10.1201/9781003157823-18.Peer-Reviewed Original ResearchBlood-brain barrierMultiple sclerosisLimitations of current therapiesNeurological disordersParkinson's diseaseHuntington's diseaseCurrent therapiesClinical studiesTransport drugsNanoparticle strategiesIntroduction of nanotechnologyNoninvasive techniqueNanoparticle technologyDiseaseDrugDamaged nervous tissuePersistent luminescence imagingAdvanced diagnosisEtiologyGold nanoparticlesBrainDisordersNervous tissueDisease treatmentSclerosisRecent Trends in Evaluating the Mechanistic Aspects of Alzheimer's Disease and Its Diagnosis with Smart Devices
Nuthalapati P, Yendapalli P, Kumar M, Joy A, Sainatham C. Recent Trends in Evaluating the Mechanistic Aspects of Alzheimer's Disease and Its Diagnosis with Smart Devices. 2022, 25-34. DOI: 10.1201/9781003157823-3.Peer-Reviewed Original ResearchAspects of Alzheimer's diseaseHealth statusAlzheimer's diseaseLack of knowledgeLoss of cognitive abilitiesStages of Alzheimer's diseaseEarly stages of Alzheimer's diseaseAlzheimer patientsChronic neurological disorderCaregiversPatientsCognitive abilitiesMental statesDementiaDiagnosisLifestylePhysiciansHealthLow diagnostic accuracyDiseaseNeurological disordersEarly diagnosisAntiproliferative Effects of Olanzapine against MCF-7 Cells and Its Molecular Interactions with Survivin
Vedam V, Nuthalapati P, Ghanta M, David D, Vijayalakshmi M, Potla K, Mary Y. Antiproliferative Effects of Olanzapine against MCF-7 Cells and Its Molecular Interactions with Survivin. International Journal Of Nutrition Pharmacology Neurological Diseases 2022, 12: 72-78. DOI: 10.4103/ijnpnd.ijnpnd_82_21.Peer-Reviewed Original ResearchAntiproliferative effects of olanzapine against MCF-7 human breast cancer cells and its molecular interactions with surviving
Nuthalapati P. Antiproliferative effects of olanzapine against MCF-7 human breast cancer cells and its molecular interactions with surviving. Brain Tumor Research And Treatment 2022, 10: s141. DOI: 10.14791/btrt.2022.10.f-2510.Peer-Reviewed Original ResearchChapter 25 Pharmacogenomics and outcomes for hepatocellular cancer treatment
Ghanta M, Hussain M, Karnalkar A, Nagabhishek S, Nuthalapati P, Bhaskar L. Chapter 25 Pharmacogenomics and outcomes for hepatocellular cancer treatment. 2022, 401-414. DOI: 10.1016/b978-0-323-99283-1.00003-3.Peer-Reviewed Original ResearchHepatocellular carcinomaEffects of systemic treatmentRisk factorsPrevalence of genetic variantsSystemic therapy efficacyHepatocellular carcinoma recurrenceHuman genomeMultiple genesSingle-geneGenetic variantsSystemic treatmentPharmacogenomicsGenetic abnormalitiesTherapy efficacyViral infectionGenetic mutationsEconomic burdenPotential targetGeographic prevalenceEfficacyGenomeFood habitsRiskGenesCarcinomaRole of CD4+ T Cells in Parkinson's Disease
Ghanta M, Nuthalapati P, Merchant N, Chenchula S, Hussain F, Ak A, Bhaskar L. Role of CD4+ T Cells in Parkinson's Disease. Critical Reviews In Immunology 2022, 42: 17-25. PMID: 37082948, DOI: 10.1615/critrevimmunol.2023047372.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cellsExpression of CD4+ T cellsCD4+ T cell phenotypePeripheral adaptive immunityT-cell phenotypeNervous systemMulti-system disorderDopaminergic neuronal lossCentral nervous systemTreatment of PDImmune dysfunctionSymptomatic treatmentAdaptive immunityCD4Disease pathogenesisNeuronal lossProgressive conditionAnti-inflammatoryDiseaseParkinson's diseaseTreatmentPhenotypeFunctional profilesPhenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report
Rathinam K, Sabarathinam S, Nuthalapati P, Mahalingam V. Phenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report. Current Drug Research Reviews 2022, 14: 80-83. PMID: 34225642, DOI: 10.2174/2589977513666210322160009.Peer-Reviewed Original ResearchConceptsStevens-Johnson syndromeCase reportInduced Stevens-Johnson syndromeNecrosis syndromePost-surgical complicationsRare caseStevens-JohnsonOffending agentNikolsky's signSupportive careNeurosurgical patientsRaised body temperatureSyndromeSyndrome overlapPhenytoinPatientsCephalexinToxicityBody temperature
2021
Molecular docking study of Momordica charantia Linn phytoconstituent with caspase 3 and implications for renoprotective actions in diabetes mellitus
Ghanta M, Nayaka S, Nuthalapati P, Afzal Khan A, Elango P, Lakkakula B. Molecular docking study of Momordica charantia Linn phytoconstituent with caspase 3 and implications for renoprotective actions in diabetes mellitus. Journal Of Nephropharmacology 2021 DOI: 10.34172/npj.2022.10394.Peer-Reviewed Original ResearchD-galacturonic acidCaspase 3Amino acid interactionsCaspase 3 enzymeAnti-apoptotic agentApoptosis executionerPDB databaseProtein structurePlant extractsCaspaseMolecular docking studiesAcid interactionsNeurodegenerative disease treatmentGlu124AutoDock versionBitter melon extractLys137Pectin compositionBitter melonMedicinal propertiesMelon extractMomordica charantiaPlantsPubChem databaseDisease treatmentAssociation of hypercoagulation with severe acute respiratory syndrome coronavirus 2 infection
Nuthalapati P, Ghanta M, Natesh N, Bhaskar L. Association of hypercoagulation with severe acute respiratory syndrome coronavirus 2 infection. Blood Research 2021, 56: 61-64. PMID: 34083499, PMCID: PMC8246040, DOI: 10.5045/br.2021.2021011.Peer-Reviewed Original ResearchLevels of clotting factorsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 infectionAssociation of hypercoagulabilityWorld Health OrganizationCoronavirus 2 infectionAntithrombotic treatmentThrombotic complicationsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Inflammatory changesRespiratory syndrome coronavirus 2Implementation of guidelinesClotting factorsPlatelet activationCerebrovascular accidentMyocardial infarctionSyndrome coronavirus 2Coronavirus disease 2019Cerebral vesselsPatientsThrombus formationHypercoagulabilityComplicationsCoronavirus 2Green Synthesis, Antioxidant, and Plant Growth Regulatory Activities of Novel α‑Furfuryl-2-alkylaminophosphonates
Nadiveedhi M, Nuthalapati P, Gundluru M, Yanamula M, Kallimakula S, Pasupuleti V, Avula V, Vallela S, Zyryanov G, Balam S, Cirandur S. Green Synthesis, Antioxidant, and Plant Growth Regulatory Activities of Novel α‑Furfuryl-2-alkylaminophosphonates. ACS Omega 2021, 6: 2934-2948. PMID: 33553912, PMCID: PMC7860093, DOI: 10.1021/acsomega.0c05302.Peer-Reviewed Original ResearchPlant growth regulatory activityQuantitative structure-activity relationshipKabachnik-Fields reactionStructure-activity relationshipGreen chemical approachGrowth regulatory activityTitle compoundIsolated yieldsSchiff baseMicrowave irradiationMolecular dockingChemical approachSilica gelAmino acid residuesGreen synthesisAcid residuesCompoundsEco-friendlyBioactivity studiesAntioxidant agentsChain CPlantsDialkylphosphitesADMETChain