1999
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Kornack D, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 5768-5773. PMID: 10318959, PMCID: PMC21935, DOI: 10.1073/pnas.96.10.5768.Peer-Reviewed Original ResearchConceptsAdult macaque monkeysDentate gyrusMacaque monkeysAdult primate hippocampusAdult rodent dentate gyrusImmunohistochemical double labelingHippocampal dentate gyrusRodent dentate gyrusDiscreet brain regionsMultipotent neural stem cellsNeural stem cellsAdult neurogenesisAdult brainPrimate hippocampusAnimal modelsBrain regionsDouble labelingNeurogenesisSpecific markersHippocampusGyrusStem cellsCell typesMonkeysHumans
1997
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang D, Kuan C, Whitmarsh A, Rinócn M, Zheng T, Davis R, Rakic P, Flavell R. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997, 389: 865-870. PMID: 9349820, DOI: 10.1038/39899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisDrug ResistanceExcitatory Amino Acid AgonistsGene ExpressionGene TargetingGlutamic AcidHippocampusKainic AcidMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 10Mitogen-Activated Protein KinasesNeuronsPhosphorylationProtein KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSeizuresSignal TransductionTranscription Factor AP-1ConceptsKainic acidGlutamate receptor agonist kainic acidAgonist kainic acidExcitotoxicity-induced apoptosisExcitatory amino acidsHippocampal neuron apoptosisHippocampus of miceStress-induced neuronal apoptosisObserved neuroprotectionGlutamate neurotoxicitySeizure activityNeuron apoptosisGlutamate toxicityNeuronal apoptosisAP-1 transcription factor complexJNK3 geneMutant miceMiceMembrane depolarizationNoxious stressTranscription factor complexApoptosisC-JunRecent studiesTranscriptional activity
1991
A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey
Eckenhoff M, Rakic P. A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey. Brain Research 1991, 64: 129-135. PMID: 1786637, DOI: 10.1016/0165-3806(91)90216-6.Peer-Reviewed Original Research
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic proteinCCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus
Leranth C, Frotscher M, Rakic P. CCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus. Histochemistry And Cell Biology 1988, 88: 343-352. PMID: 3366638, DOI: 10.1007/bf00570293.Peer-Reviewed Original ResearchConceptsSynaptic contactsMonkey hippocampusSymmetric synaptic contactsAsymmetric synaptic contactsDistribution of CCKExcitatory transmissionSymmetric synapsesDendritic shaftsPyramidal cellsRat hippocampusCA3 regionDendritic spinesPrimate hippocampusHippocampusCell bodiesRodent hippocampusSame neuropeptidesImmunocytochemical analysisPresent findingsRatsSynapsesImportant differencesAsymmetric contactsCholecystokininCA1
1984
Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey
Eckenhoff M, Rakic P. Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey. The Journal Of Comparative Neurology 1984, 223: 1-21. PMID: 6707248, DOI: 10.1002/cne.902230102.Peer-Reviewed Original Research
1983
Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study
Duffy C, Rakic P. Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study. The Journal Of Comparative Neurology 1983, 214: 224-237. PMID: 6841685, DOI: 10.1002/cne.902140210.Peer-Reviewed Original ResearchConceptsGranule cell dendritesDentate gyrusCell dendritesDendritic spinesGranule cellsRhesus monkeysPostnatal rhesus monkeysQuantitative Golgi studyHippocampal granule cellsPostnatal day 3Time of birthRapid Golgi methodLength of dendritesDendritic lengthDendritic shaftsNeonatal levelsGolgi studyDistal thirdHippocampal regionDendritic branchingAdult monkeysDay 3Postnatal developmentGolgi methodLevel of maturation
1981
The time of origin of neurons in the hippocampal region of the rhesus monkey
Rakic P, Nowakowski R. The time of origin of neurons in the hippocampal region of the rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 99-128. PMID: 7204668, DOI: 10.1002/cne.901960109.Peer-Reviewed Original ResearchConceptsHippocampal regionArea CA2Entorhinal areaArea CA1Fascia dentataGranule cellsRhesus monkeysFirst postnatal monthProduction of neuronsEmbryonic day 33Parasubicular neuronsHippocampal neurogenesisDentate gyrusArea CA4Stratum pyramidalePyramidal cellsPostnatal monthArea CA3Last neuronsHippocampal subdivisionsCell originParahippocampal formationHistological dataDay 33NeuronsThe site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey
Nowakowski R, Rakic P. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 129-154. PMID: 7204662, DOI: 10.1002/cne.901960110.Peer-Reviewed Original ResearchConceptsMicrometers/daySite of originVentricular zoneDentate gyrusHippocampal regionParahippocampal formationRhesus monkeysLateral cerebral ventricleMajority of neuronsLamina principalis externaDistinct cytoarchitectonic areasCerebral ventricleCortical plateSubventricular zoneAdjacent neocortexHippocampal formationMedial wallCytoarchitectonic areasNeuronsAnalysis of specimensThymidine autoradiographyProliferative zoneCell migrationGyrusLonger intervals
1979
The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey
Nowakowski R, Rakic P. The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. Brain Cell Biology 1979, 8: 697-718. PMID: 120417, DOI: 10.1007/bf01206671.Peer-Reviewed Original Research