1999
Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior regionIllusive transience of parvalbumin expression duringembryonic development of the primate spinal cord
Knyihár‐csillik E, Rakic P, Csillik B. Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord. International Journal Of Developmental Neuroscience 1999, 17: 79-97. PMID: 10221668, DOI: 10.1016/s0736-5748(98)00090-2.Peer-Reviewed Original ResearchConceptsNerve cellsSpinal cordLarge dorsal root ganglion cellsDorsal root ganglion cellsYoung adult macaque monkeysPrimate spinal cordUpper dorsal hornDorsal root axonsPrimary sensory neuronsSpinal reflex pathwaysElectron microscopic immunohistochemical techniquesAdult macaque monkeysParvalbumin-positive terminalsLong axonal processesDorsal hornMonkey fetusesDorsal columnsReflex pathwaysGanglion cellsClarke's nucleusAxon terminalsIntercellular networkMotoneuron poolSensory neuronsSynaptic terminals
1997
Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system
Meissirel C, Wikler K, Chalupa L, Rakic P. Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5900-5905. PMID: 9159172, PMCID: PMC20878, DOI: 10.1073/pnas.94.11.5900.Peer-Reviewed Original ResearchRadiation‐induced, lamina‐specific deletion of neurons in the primate visual cortex
Algan O, Rakic P. Radiation‐induced, lamina‐specific deletion of neurons in the primate visual cortex. The Journal Of Comparative Neurology 1997, 381: 335-352. PMID: 9133572, DOI: 10.1002/(sici)1096-9861(19970512)381:3<335::aid-cne6>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusArea 17Primate visual cortexVisual cortexLow dosesCortical layersArea 17/18 borderEmbryonic day 80Period of corticogenesisSuperficial cortical layersOnset of corticogenesisComputer-aided morphometryMacaque monkey brainSpecific cell classesMultiple dosesCortical cytoarchitectureGeniculate nucleusCortical developmentLaminar positionSpecific neuronal classesCortical thicknessPrimate brainMonkey brainCytoarchitectonic featuresHigh dosesEarly emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody
Wikler K, Rakic P, Bhattacharyya N, Macleish P. Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody. The Journal Of Comparative Neurology 1997, 377: 500-508. PMID: 9007188, DOI: 10.1002/(sici)1096-9861(19970127)377:4<500::aid-cne2>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsPrimate retinaFetal retinaMonoclonal antibodiesAdult primate retinaEmbryonic day 80Opsin-positive conesOuter plexiform layerNovel monoclonal antibodyPopulation of conesShort-wavelength sensitive conesDouble-labeling experimentsSynaptic contactsPlexiform layerPhotoreceptor layerWavelength-sensitive conesMacaque monkeysSynaptic connectionsFetal ageRetinaDay 80Cone genesisCone opsinsImmunoreactivityAntibodiesInitial differentiation
1996
Synaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages
Bourgeois J, Rakic P. Synaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages. European Journal Of Neuroscience 1996, 8: 942-950. PMID: 8743742, DOI: 10.1111/j.1460-9568.1996.tb01581.x.Peer-Reviewed Original ResearchConceptsAge-matched controlsStriate cortexDendritic spinesSynaptic contactsRetinal inputInfragranular cortical layersRatio of synapsesLateral geniculate nucleusPrimate striate cortexVolume of neuropilGroups of animalsEarly embryonic stagesAsymmetrical synapsesInfragranular layersSynaptic organizationGeniculate nucleusOccipital cortexNormal rangeOperated animalsSynaptic circuitsMacaque monkeysCortical layersEnucleated animalsSynaptic developmentDay 67
1995
Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe
Lidow M, Rakic P. Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe. The Journal Of Comparative Neurology 1995, 360: 393-402. PMID: 8543647, DOI: 10.1002/cne.903600303.Peer-Reviewed Original ResearchConceptsCortical neuronsOccipital lobeReceptor subtypesSubventricular zoneHigh-affinity kainate receptorsProliferative zoneSubventricular proliferative zonesNeurotransmitter receptor subtypesCell proliferationEmbryonic cerebral wallGamma-aminobutyric acidD1 dopaminergicMonkey fetusesDeep laminaeKainate receptorsNeuronal productionCerebral wallMultiple neurotransmittersCortical neurogenesisNeurotransmitter receptorsVisual cortexFetusesNeuronsAlpha 1Alpha 2Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages
Rakic P, Lidow. Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages. Journal Of Neuroscience 1995, 15: 2561-2574. PMID: 7891189, PMCID: PMC6578103, DOI: 10.1523/jneurosci.15-03-02561.1995.Peer-Reviewed Original ResearchConceptsMonoamine receptorsVisual cortexLaminar distributionSpecific laminar patternMonths of agePrimate visual cortexGroups of animalsBinocular enucleationCortical consequencesPrestriate areasCerebral cortexMonoaminergic receptorsSupragranular layersCortical plateLayer IVCongenital anophthalmiaGeniculocortical fibersOccipital lobeCortical bindingLaminar patternRetinal inputNeurotransmitter receptorsMonkey striateCoronal planeDistinct laminar
1992
Genesis of neurons in the retinal ganglion cell layer of the monkey
Rapaport D, Fletcher J, LaVail M, Rakic P. Genesis of neurons in the retinal ganglion cell layer of the monkey. The Journal Of Comparative Neurology 1992, 322: 577-588. PMID: 1401251, DOI: 10.1002/cne.903220411.Peer-Reviewed Original ResearchConceptsRetinal ganglion cell layerGanglion cell layerCell layerEmbryonic day 38Genesis of neuronsSomata of cellsMedium-sized cellsEnd of neurogenesisAmacrine cellsSmall somataPrimate retinaSoma diameterNeuronal classesSequential scheduleDay 38Rhesus monkeysSmall caliberNeuronsAlpha cellsRetinaMicrons diameterSomaMonkeysCellsE38
1991
Cytogenesis in the monkey retina
la Vail M, Rapaport D, Rakic P. Cytogenesis in the monkey retina. The Journal Of Comparative Neurology 1991, 309: 86-114. PMID: 1894769, DOI: 10.1002/cne.903090107.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyDNA ReplicationGestational AgeMacacaRetinaRetinal Ganglion CellsThymidineTritiumRelation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina
Wikler K, Rakic P. Relation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina. Nature 1991, 351: 397-400. PMID: 1827876, DOI: 10.1038/351397a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationEye ProteinsGestational AgeImmunologic TechniquesMacaca mulattaPhotoreceptor CellsRetinaRod OpsinsConceptsSubset of conesCone subtypesAdult rhesus monkeysRetinal mosaicsBlue-sensitive conesPrimate retinaRetinal surfaceImmunocytochemical evidenceRhesus monkeysPhenotypic specificationInner segmentsConfocal laser microscopySubtypesRetinaWeeksUndifferentiated regionDiurnal primatesLaser microscopyMonthsSynapses
1990
Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain
Kostovic I, Rakic P. Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. The Journal Of Comparative Neurology 1990, 297: 441-470. PMID: 2398142, DOI: 10.1002/cne.902970309.Peer-Reviewed Original ResearchConceptsSubplate zoneTransient subplate zoneCortical plateSomatosensory cortexSubcortical white matterSubplate neuronsBasal forebrainBrain stemContralateral cerebralGlial cellsPostmigratory neuronsSomatosensory areaFetal brainOccipital lobeCerebral convolutionsCerebral wallFiber terminalsHuman fetusesWhite matterMacaque monkeysVisual areasCortexGestationFiber-rich layersHistochemical methodsNeurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey
Kordower J, Rakic P. Neurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey. The Journal Of Comparative Neurology 1990, 291: 637-653. PMID: 2329194, DOI: 10.1002/cne.902910410.Peer-Reviewed Original ResearchConceptsBasal forebrain nucleiMagnocellular basal forebrain nucleiBasal forebrainForebrain nucleiRhesus monkeysAnterior basal forebrainEmbryonic day 27Early postnatal periodPeak of neurogenesisCortical-cortical connectionsNucleus basalisNeurogenic gradientCortical neuronsDays gestationMagnocellular neuronsPostnatal periodTarget neuronsNeuronal genesisCortical mantleMagnocellular nucleusPregnant animalsDay 27Intermediate divisionGestationPosterior division
1984
Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining
Kostovic I, Rakic P. Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining. Journal Of Neuroscience 1984, 4: 25-42. PMID: 6693940, PMCID: PMC6564757, DOI: 10.1523/jneurosci.04-01-00025.1984.Peer-Reviewed Original ResearchConceptsPrestriate cortexSubplate zoneCholinesterase stainingChE activityAdjacent neocortical areasPrestriate visual cortexCholinesterase-positive fibersHuman fetal cerebrumNucleus pulvinarisPulvinar inputStage VSubcortical projectionsThalamic nucleiArea 17Fetal brainOccipital lobeNeocortical areasStage IStage IIIStage IVLayer IIIVisual cortexLayer IFetal cerebrumStage II
1983
Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone
Levitt P, Cooper M, Rakic P. Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone. Developmental Biology 1983, 96: 472-484. PMID: 6339301, DOI: 10.1016/0012-1606(83)90184-7.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinVentricular zoneRhesus monkey fetusesPrecursor cellsFibrillary acidic proteinGFA-positive cellsCerebral ventricular zoneGlial precursor cellsNeuronal precursor cellsMonkey fetusesGestational periodProliferative ventricular zoneOccipital lobePrimate brainImmunocytochemical stainingAcidic proteinMitotic figuresCellular compositionEmbryonic ageCellsElectron microscopic analysisEarly divergenceFetusesPresent resultsNeurons
1981
Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey
Cooper M, Rakic P. Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey. The Journal Of Comparative Neurology 1981, 202: 309-334. PMID: 7298901, DOI: 10.1002/cne.902020303.Peer-Reviewed Original ResearchConceptsSuperior colliculusInferior colliculusCentral nucleusInferior colliculiRhesus monkeysVentrodorsal gradientLateral-medial gradientAnterior-posterior gradientTectal neuronsNeurogenetic gradientsPeak proliferationSubventricular zoneSelective cell deathRostrocaudal gradientCNS cellsFinal mitosisNeuronsDistinctive spatiotemporal patternsNeurogenesisEmbryonic dayColliculiColliculusGestation periodCell deathLateral cell movementThe genesis of efferent connections from the visual cortex of the fetal rhesus monkey
Shatz C, Rakic P. The genesis of efferent connections from the visual cortex of the fetal rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 287-307. PMID: 7217358, DOI: 10.1002/cne.901960208.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusInfragranular cortical layersFetal rhesus monkeysSuperior colliculusRhesus monkeysCortical projectionsPyramidal neuronsVisual cortexCortical layersSubcortical structuresDorsal lateral geniculate nucleusTopographic orderCell-poor zoneCorticogeniculate projectionsSuperficial grayAfferent pathwaysCortical efferentsCortical injectionsEfferent pathwaysCortical plateDendritic arborizationArea 17Pyramidal cellsEfferent connectionsGeniculate nucleus
1980
Neurogenesis of the nucleus accumbens septi and neighboring septal nuclei in the rhesus monkey: A combined [3H]thymidine and electron microscopic study
Brand S, Rakic P. Neurogenesis of the nucleus accumbens septi and neighboring septal nuclei in the rhesus monkey: A combined [3H]thymidine and electron microscopic study. Neuroscience 1980, 5: 2125-2138. PMID: 7465048, DOI: 10.1016/0306-4522(80)90128-1.Peer-Reviewed Original ResearchConceptsNucleus accumbens septiMedial septal nucleusSeptal nucleusAccumbens septiRhesus monkeysEmbryonic day 45Lateral septal nucleusEarly postnatal daysPattern of neurogenesisCommon embryological originDifferent embryonic daysPostnatal dayNeuronal productionNucleus accumbensNeuron distributionDay 85SeptiPrimate neostriatumPial surfaceOld monkeysDay 45NeuronsElectron microscopic studyEmbryological originAutoradiographic analysisCytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon
Kostovic I, Rakic P. Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. Brain Cell Biology 1980, 9: 219-242. PMID: 7441294, DOI: 10.1007/bf01205159.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAdultAnimalsGestational AgeHumansInfantMacaca mulattaNeuronsOrganoidsSynapsesTelencephalonConceptsInterstitial neuronsMonkey telencephalonWhite matterInterstitial cellsSomatosensory motor cortexDeep neocortical layersEarly postnatal daysRapid Golgi impregnationsCentral nervous systemSpecific AChE activityGeneration of neuronsAxodendritic synapsesNeonatal periodMotor cortexSubplate layerSynaptic relationshipsNeurons decreasesPostnatal dayAcetylcholinesterase histochemistryGolgi impregnationNervous systemNeocortical layersRhesus monkeysFusiform cellsPolymorphic cells
1979
The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey
Nowakowski R, Rakic P. The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. Brain Cell Biology 1979, 8: 697-718. PMID: 120417, DOI: 10.1007/bf01206671.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCell MovementCytoplasmGestational AgeHaplorhiniHippocampusMacaca mulattaNerve FibersNeuronsOrganoidsConceptsPostmitotic young neurons