2024
Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors
Morozov Y, Rakic P. Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors. Cerebral Cortex 2024, 34: bhae293. PMID: 39024157, PMCID: PMC11485267, DOI: 10.1093/cercor/bhae293.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProgenitor cellsVentricular zoneCerebral cortexBasolateral cell membraneApical anchorageProlonged neurogenesisMammalian cerebral cortexPrimary ciliaApical neural progenitorsCell membraneFraction of cellsNeural progenitorsStem cellsCerebral neurogenesisApical segmentsDevelopment of ciliaNuclear translocationMicrotubule organizing centerNeurogenesisCellsMacaque monkeysSpecies-specific differencesCortexBasal bodies
2023
Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
Junaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure And Function 2023, 228: 613-633. PMID: 36592215, PMCID: PMC9944618, DOI: 10.1007/s00429-022-02606-7.Peer-Reviewed Original Research
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2009
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009, 461: 524-528. PMID: 19759535, PMCID: PMC2874978, DOI: 10.1038/nature08362.Peer-Reviewed Original ResearchConceptsNeocortical excitatory neuronsRadial glial fibersColumnar organizationEphA/ephrinCerebral cortexFunctional impairmentNeuronal clonesExcitatory neuronsGlial fibersTangential migrationCortical columnsNeural progenitorsCircuit developmentEphrinProliferative unitsPopulationClonal populationsCortexNeuronsExocyst is involved in polarized cell migration and cerebral cortical development
Letinic K, Sebastian R, Toomre D, Rakic P. Exocyst is involved in polarized cell migration and cerebral cortical development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11342-11347. PMID: 19549839, PMCID: PMC2708724, DOI: 10.1073/pnas.0904244106.Peer-Reviewed Original ResearchConceptsCell migrationDelivery of vesiclesNeuronal migrationVesicle tetheringExocyst complexMembrane trafficExocytic pathwayProtein complexesExocytic processExocystSpatial regulationEmbryonic developmentVesicle exocytosisSecretory vesiclesPlasma membraneTIRF microscopyPostmitotic cellsCortical neuronal migrationProper developmentCerebral cortical developmentWound assaysExocytosisVesiclesMembraneCellsDecision by division: making cortical maps
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends In Neurosciences 2009, 32: 291-301. PMID: 19380167, PMCID: PMC3601545, DOI: 10.1016/j.tins.2009.01.007.Peer-Reviewed Original ResearchConceptsNeuronal fate determinationFate determinationFinal mitotic divisionEvolutionary expansionCell determinationMitotic divisionProtomap hypothesisEarly specificationLatest compendiumBiological basisProliferative zoneNeuronal classesNewborn neuronsBroad spectrumDivisionGenesHuman neocortexCortical malformationsNeuronsRadial unitsCompendiumMigrationCerebral wall
2001
Neurocreationism--Making New Cortical Maps
Rakic P. Neurocreationism--Making New Cortical Maps. Science 2001, 294: 1011-1012. PMID: 11691974, DOI: 10.1126/science.294.5544.1011.Peer-Reviewed Original ResearchDevelopment of Layer I Neurons in the Primate Cerebral Cortex
Zecevic N, Rakic P. Development of Layer I Neurons in the Primate Cerebral Cortex. Journal Of Neuroscience 2001, 21: 5607-5619. PMID: 11466432, PMCID: PMC6762645, DOI: 10.1523/jneurosci.21-15-05607.2001.Peer-Reviewed Original ResearchConceptsCerebral cortexLayer ILayer I cellsLayer I neuronsPrimate cerebral cortexCajal-Retzius cellsSubpial granular layerGABAergic neuronsGABAergic interneuronsCortical plateI neuronsGanglionic eminenceMacaque monkeysPial surfaceOlfactory primordiumI cellsNeuronsMonth periodLong gestationGranular layerCortexUltrastructural analysisCorticogenesisCellsPrimates
1999
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan N, Artavanis-Tsakonas S, Rakic P. Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling. Science 1999, 286: 741-746. PMID: 10531053, DOI: 10.1126/science.286.5440.741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell CountCell DifferentiationCell MovementCell NucleusCell SizeCells, CulturedCerebral CortexContact InhibitionHumansLigandsMembrane ProteinsMiceMitosisNeuritesNeuronsProtein Structure, TertiaryReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceSignal TransductionTranscription FactorsTranscriptional ActivationUp-RegulationConceptsNeurite growthMouse cerebral cortexCapacity of neuronsCortical neurite growthStudy of neuronsInhibition of NotchCerebral cortexNotch signalingCortical neuronsNotch activityMature neuronsInterneuronal contactsRetraction of neuritesHigh Notch activityNeuronsNeuronal growthNeuritesContact-dependent inhibitionExuberant growthNeurite extensionNotch receptorsInhibitionLow Notch activitySignalingActivityGenetic Control of Cortical Development
Rubenstein J, Rakic P. Genetic Control of Cortical Development. Cerebral Cortex 1999, 9: 521-523. PMID: 10498269, DOI: 10.1093/cercor/9.6.521.Peer-Reviewed Original ResearchMolecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior regionDistinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1998
Brain Development, VI: Radial Migration and Cortical Evolution
RAKIC P. Brain Development, VI: Radial Migration and Cortical Evolution. American Journal Of Psychiatry 1998, 155: 1150-1151. PMID: 9734535, DOI: 10.1176/ajp.155.9.1150.Peer-Reviewed Original ResearchDevelopment of the Cerebral Cortex: I. Forming the Cortical Structure
Rakic P, Lombroso P. Development of the Cerebral Cortex: I. Forming the Cortical Structure. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 116-117. PMID: 9444908, DOI: 10.1097/00004583-199801000-00026.Peer-Reviewed Original Research
1997
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration
1996
Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
Anton E, Cameron R, Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. Journal Of Neuroscience 1996, 16: 2283-2293. PMID: 8601808, PMCID: PMC6578523, DOI: 10.1523/jneurosci.16-07-02283.1996.Peer-Reviewed Original ResearchConceptsEmbryonic cerebral wallCerebral wallNeuronal migrationCerebral cortexNeuronal migratory pathwayRadial glial cell processesRadial glial fibersGlial cell processesNormal neuronal migrationCortical plateSlice preparationAntibody exposureGlial fibersMarginal zone regionsMonoclonal antibodiesAntibodiesNeuronsCortexCell substratesMarginal zonePolyclonal antiserumMicrotubular organizationCell processesMigratory pathwaysCell detachment
1995
Radial versus tangential migration of neuronal clones in the developing cerebral cortex.
Rakic P. Radial versus tangential migration of neuronal clones in the developing cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11323-11327. PMID: 8524778, PMCID: PMC40392, DOI: 10.1073/pnas.92.25.11323.Peer-Reviewed Original ResearchTempo of neurogenesis and synaptogenesis in the primate cingulate mesocortex: Comparison with the neocortex
Granger B, Tekaia F, Le Sourd A, Rakic P, Bourgeois J. Tempo of neurogenesis and synaptogenesis in the primate cingulate mesocortex: Comparison with the neocortex. The Journal Of Comparative Neurology 1995, 360: 363-376. PMID: 8522653, DOI: 10.1002/cne.903600212.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexGyrus CinguliLimbic SystemMacaca mulattaMicroscopy, ElectronNeural PathwaysSynapsesConceptsEnd of neurogenesisArea 24Area 17Neocortical areasEmbryonic days (EDs) 70Postnatal rhesus monkeysSecond postnatal monthPrimary visual cortexRemainder of gestationAnterior cingulate cortexSynaptic densityPostnatal monthRapid phaseHumoral factorsCingulate cortexVisual cortexAssociational areasRhesus monkeysNeurogenesisDay 70SynaptogenesisAutoradiographic analysisMonthsMesocortexNeocortexA small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution
Rakic P. A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution. Trends In Neurosciences 1995, 18: 383-388. PMID: 7482803, DOI: 10.1016/0166-2236(95)93934-p.Peer-Reviewed Original ResearchRadial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages
Kornack D, Rakic P. Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages. Neuron 1995, 15: 311-321. PMID: 7646888, DOI: 10.1016/0896-6273(95)90036-5.Peer-Reviewed Original Research