Safety Outcomes of Antiplatelet Therapy During Endovascular Treatment of Tandem Lesions in Acute Ischemic Stroke Patients
Farooqui M, Divani A, Galecio-Castillo M, Hassan A, Jumaa M, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Ikram A, Tekle W, Zaidi S, Zevallos C, Rizzo F, Barkley T, De Leacy R, Khalife J, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Rodriguez-Calienes A, Vivanco-Suarez J, Turabova C, Mokin M, Yavagal D, Ortega-Gutierrez S. Safety Outcomes of Antiplatelet Therapy During Endovascular Treatment of Tandem Lesions in Acute Ischemic Stroke Patients. Translational Stroke Research 2023, 1-11. PMID: 38017258, PMCID: PMC11271812, DOI: 10.1007/s12975-023-01214-9.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageEndovascular therapyIn-stent thrombosisTandem lesionsAnterior circulation tandem lesionsRate of symptomatic hemorrhageFavorable functional statusTreatment of tandem lesionsRisk of hemorrhageAcute ischemic stroke patientsNo significant associationExcellent reperfusionIschemic stroke patientsSymptomatic hemorrhageMRS 0Intracranial hemorrhageAntiplatelet strategiesEndovascular treatmentMulticenter studyAntiplatelet therapyAntiplatelet medicationsAntiplatelet regimensMTICI 2c/3Carotid stentingPrimary outcomeLow dose intravenous cangrelor versus glycoprotein IIb/IIIa inhibitors in endovascular treatment of tandem lesions
Jumaa M, Rodriguez-Calienes A, Dawod G, Vivanco-Suarez J, Hassan A, Divani A, Oliver M, Ribo M, Petersen N, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Galecio-Castillo M, Zevallos C, Malaga M, Farooqui M, Jovin T, Zaidi S, Ortega-Gutierrez S. Low dose intravenous cangrelor versus glycoprotein IIb/IIIa inhibitors in endovascular treatment of tandem lesions. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107438. PMID: 37883826, PMCID: PMC11271813, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107438.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageGP IIb/IIIa inhibitorsRate of symptomatic intracranial hemorrhageGP IIb/IIIaAntiplatelet therapyMechanical thrombectomyRetrospective non-randomized cohort studyGP IIb/IIIa inhibitor groupHemorrhagic infarction type 1Tandem lesionsComplete reperfusionType 1Periprocedural antiplatelet therapyReducing hemorrhage ratesParenchymal hematoma type 1Treatment of tandem lesionsNon-randomized cohort studyAcute carotid stentingIntravenous (IVGlycoprotein IIb/IIIa inhibitorsRate of complete reperfusionAssociated with increased oddsCangrelor groupHemorrhage rateIntravenous cangrelor