2024
Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria
Sariyeva M, Haghighi N, Mitchell A, Booker W, Petersen N, Shields A, Ghoshal S, Agarwal S, Park S, Claassen J, Connolly E, Roh D, Miller E. Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria. Journal Of The American Heart Association 2024, 13: e034032. PMID: 38533990, PMCID: PMC11179753, DOI: 10.1161/jaha.123.034032.Peer-Reviewed Original ResearchNonpregnant womenSecondary intracerebral hemorrhagePrimary intracerebral hemorrhageNontraumatic intracerebral hemorrhageIntracerebral hemorrhageIntracerebral hemorrhage pathogenesisIntracerebral hemorrhage characteristicsIn-hospital mortality rateYoung adultsCohort of young adultsTime of dischargeMaternal morbidityNonpregnant adultsUnique pathophysiologyRetrospective analysisFunctional outcomesOdds ratioMortality ratePathogenesisSmall vesselsWomenHemorrhageOddsPathophysiologyMenUncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan
Tran A, Zeevi T, Haider S, Abou Karam G, Berson E, Tharmaseelan H, Qureshi A, Sanelli P, Werring D, Malhotra A, Petersen N, de Havenon A, Falcone G, Sheth K, Payabvash S. Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan. Npj Digital Medicine 2024, 7: 26. PMID: 38321131, PMCID: PMC10847454, DOI: 10.1038/s41746-024-01007-w.Peer-Reviewed Original ResearchDeep learning modelsHematoma expansionIntracerebral hemorrhageICH expansionComputed tomographyNon-contrast head CTNon-contrast head computed tomographyHigh risk of HEHead computed tomographyHigh-confidence predictionsRisk of HENon-contrast headReceiver operating characteristic areaModifiable risk factorsMonte Carlo dropoutOperating characteristics areaPotential treatment targetHead CTVisual markersIdentified patientsAutomated deep learning modelDataset of patientsRisk factorsHigh riskPatients
2023
Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingIntracerebral hemorrhageClinical informationYale-New Haven HospitalAssociation of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke
Stulberg E, Harris B, Zheutlin A, Delic A, Sheibani N, Anadani M, Yaghi S, Petersen N, de Havenon A. Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke. Neurology 2023, 101: e1145-e1157. PMID: 37487742, PMCID: PMC10513881, DOI: 10.1212/wnl.0000000000207599.Peer-Reviewed Original ResearchConceptsAverage real variabilityNonstroke patientsDischarge destinationHospital deathIschemic strokeIll patientsIllness severityWorse outcomesAdult intensive care unit patientsMinimum mean arterial pressureIntensive care unit patientsIntensive Care III databaseBlood pressure goalsAcute ischemic strokeMean arterial pressureBlood pressure variabilityCare unit patientsRisk of deathMedical Information MartUnit patientsArterial pressureIntracerebral hemorrhageSubarachnoid hemorrhageRisk factorsEffect modificationClinical and Radiological Features of Intracerebral Hemorrhage in Pregnant and Postpartum Patients (P11-5.007)
Sariyeva M, Haghighi N, Booker W, Petersen N, Marshall R, Miller E. Clinical and Radiological Features of Intracerebral Hemorrhage in Pregnant and Postpartum Patients (P11-5.007). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202955.Peer-Reviewed Original ResearchEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studiesChronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729)
Leasure A, Vanent K, Acosta J, Woo D, Murthy S, Kamel H, Cohen J, Townsend R, Petersen N, Sansing L, Gill T, Sheth K, Falcone G. Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2729.Peer-Reviewed Original Research