2018
1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study
Messacar K, Sillau S, Hopkins S, Otten C, Wilson-Murphy M, Wong B, Santoro J, Treister A, Tokhie H, Torres A, Zabrocki L, Glanternik J, Hurst A, Martin J, Schreiner T, Makhani N, DeBiasi R, Kruer M, Tremoulet A, Van Haren K, Desai J, Benson L, Gorman M, Abzug M, Tyler K, Dominguez S. 1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study. Open Forum Infectious Diseases 2018, 5: s546-s546. PMCID: PMC6254028, DOI: 10.1093/ofid/ofy210.1557.Peer-Reviewed Original ResearchAcute flaccid myelitisFluoxetine-treated patientsSerious adverse eventsMulticenter cohort studyEfficacy of fluoxetineEV-D68Cohort studyInitial examinationSevere paralysisRetrospective multicenter cohort studyPoor long-term outcomesAdverse effectsDose of fluoxetinePropensity-adjusted analysisLong-term disabilityLong-term outcomesPotential antiviral therapiesUntreated controlsAdverse eventsMost patientsEfficacy signalsPrimary outcomeAntiviral therapyStudy criteriaEffective therapy
2009
Cyclophosphamide therapy in pediatric multiple sclerosisSYMBOLSYMBOL
Makhani N, Gorman MP, Branson HM, Stazzone L, Banwell BL, Chitnis T. Cyclophosphamide therapy in pediatric multiple sclerosisSYMBOLSYMBOL. Neurology 2009, 72: 2076-2082. PMID: 19439723, PMCID: PMC2923592, DOI: 10.1212/wnl.0b013e3181a8164c.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAge of OnsetChildCyclophosphamideDisease ProgressionDrug Administration ScheduleDrug ResistanceFemaleGlatiramer AcetateHumansImmunosuppression TherapyImmunosuppressive AgentsInterferon-betaMaleMitoxantroneMultiple SclerosisPeptidesRetrospective StudiesSecondary PreventionSex DistributionTreatment OutcomeConceptsMultiple sclerosisTreatment of childrenInduction therapyMaintenance therapyTreatment initiationDisability Status Scale scoreAggressive multiple sclerosisFirst-line therapyRetrospective chart reviewMajority of patientsStatus Scale scoreCyclophosphamide therapyChart reviewDisability scoresMost patientsMulticenter experienceMultiple relapsesRelapse ratePatient selectionTransient alopeciaBladder carcinomaTreatment administrationCyclophosphamideSide effectsScale score