2024
Genetic Testing for Monogenic Stroke
Herrada S, Sunmonu N, Meschia J, Worrall B, Greene C, Kittner S. Genetic Testing for Monogenic Stroke. Stroke 2024, 55: 2946-2955. PMID: 39502078, PMCID: PMC11588536, DOI: 10.1161/strokeaha.124.047435.Peer-Reviewed Original ResearchBrain Health Outcomes in Sexual and Gender Minority Groups: Results From the All of Us Research Program.
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Sunmonu N, de Havenon A, Sarpong D, Rosendale N, Sheth K, Falcone G. Brain Health Outcomes in Sexual and Gender Minority Groups: Results From the All of Us Research Program. Neurology 2024, 103: e209863. PMID: 39321407, DOI: 10.1212/wnl.0000000000209863.Peer-Reviewed Original ResearchConceptsBrain health outcomesSexual minoritiesGender minoritiesSGM groupHealth outcomesSGM personsLate-life depressionGender identitySexual orientationHigher odds of dementiaUS population-based studyElectronic health record dataOdds of dementiaHealth record dataGender minority groupsPopulation-based studyOdds of strokeCross-sectional studyMultivariate logistic regressionHealth disparitiesBaseline questionnaireNon-SGMSubgroups of genderTransgender womenUS adultsEditorial: Diversity in stroke omic(s) and epidemiology research: opportunities and challenges
Sunmonu N, Keene K, Hyacinth H. Editorial: Diversity in stroke omic(s) and epidemiology research: opportunities and challenges. Frontiers In Stroke 2024, 3: 1421083. DOI: 10.3389/fstro.2024.1421083.Peer-Reviewed Original Research2024 AHA/ASA Performance and Quality Measures for Spontaneous Intracerebral Hemorrhage: A Report From the American Heart Association/American Stroke Association
Ruff I, de Havenon A, Bergman D, Dugue R, Frontera J, Goldstein J, Hemphill J, Marulanda-Londono E, Prabhakaran S, Richards C, Sunmonu N, Vilar P, Wolfe S. 2024 AHA/ASA Performance and Quality Measures for Spontaneous Intracerebral Hemorrhage: A Report From the American Heart Association/American Stroke Association. Stroke 2024, 55: e199-e230. PMID: 38695183, DOI: 10.1161/str.0000000000000464.Peer-Reviewed Original ResearchAmerican Heart Association/American Stroke AssociationStroke AssociationQuality measuresPosthospital settingPatient careStroke expertsData collectionWorking GroupPerformance measuresSpontaneous intracerebral hemorrhageAmericanGuidelinesIntracerebral hemorrhageAssociationPrehospitalCareAHA/ASAPotential challengesInterventionSickle Cell Disease
Sunmonu N, Adams R, Karkoska K, Hyacinth H. Sickle Cell Disease. 2024, 51-87. DOI: 10.1007/978-3-031-41777-1_4.Peer-Reviewed Original ResearchBrain Health Outcomes in Sexual and Gender Minority Groups (S14.002)
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Sunmonu N, De Havenon A, Sheth K, Falcone G. Brain Health Outcomes in Sexual and Gender Minority Groups (S14.002). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205825.Peer-Reviewed Original ResearchOral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001)
Rivier C, Clocchiatti-Tuozzo S, Huo S, Renedo D, Hawkes M, Sunmonu N, Sheth K, Falcone G. Oral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204999.Peer-Reviewed Original ResearchFirst Reported Case of Tenecteplase for Pediatric Acute Ischemic Stroke (P7-5.021)
Elmashad A, Fung C, Chakravartty A, Mehta A, Hebert R, Beekman R, Sunmonu N. First Reported Case of Tenecteplase for Pediatric Acute Ischemic Stroke (P7-5.021). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205076.Peer-Reviewed Original ResearchPredictors of stroke literacy among African Americans in the “buckle of the stroke belt”
Sunmonu N, Malek A, Jenkins C, Hyacinth H. Predictors of stroke literacy among African Americans in the “buckle of the stroke belt”. Frontiers In Stroke 2024, 3: 1331085. DOI: 10.3389/fstro.2024.1331085.Peer-Reviewed Original ResearchKnowledge of stroke signsStroke literacyStroke signsStroke BeltStroke signs and symptomsReduce stroke-related disabilityAssociated with racial disparitiesStroke-related disabilityAfrican American adultsHigh school educationStroke knowledgeHealth disparitiesAcute stroke treatmentSocioeconomic statusRacial disparitiesSocioeconomic factorsSociodemographic aspectsAmerican adultsEducation levelAdequate knowledgeAfrican AmericansEducation programsSchool educationStroke outcomeEmergency roomDiversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis
Aldridge C, Armstrong N, Sunmonu N, Becker C, Palakshappa D, Lindgren A, Pedersen A, Stanne T, Jern C, Maguire J, Hsu F, Keene K, Sale M, Irvin M, Worrall B. Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis. Frontiers In Stroke 2024, 3: 1338636. DOI: 10.3389/fstro.2024.1338636.Peer-Reviewed Original ResearchPolygenic risk scoresAncestral groupsGenome-wide significant variantsGenome-wide association study meta-analysisGenetic riskRecurrent stroke riskGWAS modelsEffective allelesRisk of incident strokeGenetic lociAssociated with incident ischemic strokeRecurrent strokeStudy meta-analysisSignificant variantsStroke riskIncident ischemic strokeGenetic studiesBiological insightsEuropean ancestryGenetic associationGenesMYH11 geneBiological relevanceLong-term disabilityGWASNeighborhood Deprivation, Race, Ethnicity, and Undiagnosed Hypertension: Results From the All of Us Research Program
Rivier C, Renedo D, Sunmonu N, de Havenon A, Sheth K, Falcone G. Neighborhood Deprivation, Race, Ethnicity, and Undiagnosed Hypertension: Results From the All of Us Research Program. Hypertension 2024, 81: e10-e12. PMID: 38232143, PMCID: PMC10962384, DOI: 10.1161/hypertensionaha.123.22055.Peer-Reviewed Original Research
2023
Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank.
Rivier C, Renedo D, de Havenon A, Sunmonu N, Gill T, Payabvash S, Sheth K, Falcone G. Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank. Neurology 2023, 102: e208010. PMID: 38165331, PMCID: PMC10870735, DOI: 10.1212/wnl.0000000000208010.Peer-Reviewed Original ResearchConceptsPoor oral healthOral healthBrain healthRisk factorsNeuroimaging markerWMH volumeHealth profileMD scoreSelf-reported poor oral healthCross-sectional neuroimaging studiesFractional anisotropyWhite matter hyperintensity volumeModifiable risk factorsWhite matter injuryPresence of denturesMendelian randomizationMiddle-aged personsFA scoreMiddle-aged participantsLoose teethCardiovascular diseaseHyperintensity volumeBrain MRIModifiable processEarly interventionUnderstanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data
de Havenon A, Bangad A, Skolarus L, Aldridge C, Braun R, Cole J, Cramer S, Lindgren A, Sunmonu N, Worrall B, Lohse K. Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data. Stroke 2023, 54: e201-e202. PMID: 36896708, PMCID: PMC10133020, DOI: 10.1161/strokeaha.122.042168.Peer-Reviewed Original ResearchAbstract WP189: Association Between Neighborhood Socioeconomic Characteristics, Cardiovascular Health, And Incidence Of Stroke
Palakshappa D, Armstrong N, Tanner R, Keene K, Hsu F, Irvin M, Aldridge C, Sunmonu N, Worrall B. Abstract WP189: Association Between Neighborhood Socioeconomic Characteristics, Cardiovascular Health, And Incidence Of Stroke. Stroke 2023, 54: awp189-awp189. DOI: 10.1161/str.54.suppl_1.wp189.Peer-Reviewed Original ResearchLife's Simple 7Neighborhood socioeconomic characteristicsCardiovascular healthStroke incidenceIncidence of strokeAmerican Heart Association's Life's Simple 7Life's Simple 7 scoreLevels of cardiovascular healthSocioeconomic characteristicsCohort study of blacksNeighborhood socioeconomic conditionsStroke riskAssociated with increased stroke riskPublic health strategiesCohort of BlackLongitudinal cohort studyCensus tract levelCox proportional hazards modelsStudy of BlackEvaluate cardiovascular healthHealth behaviorsProportional hazards modelHealth strategiesWhite adultsSocioeconomic status
2022
Characteristics of Cerebral Cavernous Malformations in a Large Multiethnic Cohort (P7-10.009)
Sunmonu N, Aldridge C, Worrall B. Characteristics of Cerebral Cavernous Malformations in a Large Multiethnic Cohort (P7-10.009). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3394.Peer-Reviewed Original ResearchAbstract WMP107: Back To The Future: Recurrent Stroke Genome Wide Association Study
Aldridge C, Armstrong N, Sunmonu N, Hsu F, Keene K, Sale M, Worrall B. Abstract WMP107: Back To The Future: Recurrent Stroke Genome Wide Association Study. Stroke 2022, 53: awmp107-awmp107. DOI: 10.1161/str.53.suppl_1.wmp107.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsCadherin-8Novel single nucleotide polymorphismsBiallelic single nucleotide polymorphismsGenome wide association studiesGenetic Reference PanelTOPMed imputation serverRecurrent strokeImputation ServerIntergenic regionAssociation studiesChromosome 1Ancestry distributionReference panelImputation qualityCox proportional hazards modelsNucleotide polymorphismsPopulation ancestryGenotyped samplesTOPMedMixed ancestryProportional hazards modelPotential new insightsChromosomeGenes
2021
First report: Rare RNF213 variant associated with familial moyamoya disease in an African American family
Sunmonu N, Ambati N, Thomas M, Ulep R, Worrall B. First report: Rare RNF213 variant associated with familial moyamoya disease in an African American family. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106123. PMID: 34666234, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106123.Peer-Reviewed Original ResearchConceptsMoyamoya diseaseAfrican American familiesEthnically diverse participantsPotential genetic susceptibilityFamilial moyamoya diseaseFirst-degree relativesAmerican familiesLate presentationFatal courseNeurological eventsRNF213 geneMild diseasePhenotypic spectrumNeurovascular imagingThalamic strokeFatal childhood diseaseIschaemic infarctionYoung probandsGenetic susceptibilityHeritable genetic diseaseDiverse participantsChildhood diseasesDiseaseGenetic diseasesRNF213Abstract P588: A Rare RNF213 Variant is Associated With Moyamoya Disease in an African American Family
Sunmonu N, Thomas M, Ulep R, Ambati N, Worrall B. Abstract P588: A Rare RNF213 Variant is Associated With Moyamoya Disease in an African American Family. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p588.Peer-Reviewed Original ResearchAfrican American familiesFamilial moyamoya diseaseEthnically diverse participantsRelatives of probandsPotential genetic susceptibilityMoyamoya diseaseAmerican familiesCerebrovascular imagingFamily historyGenetic testingRNF213 variantsLate presentationPaternal half-brothersGenetic susceptibilityAssociated with moyamoya diseaseDiverse participantsEthnic backgroundChildhood diseasesBody of evidenceResidual neurological deficitsFatal childhood diseaseAsymptomatic relativesGrowing body of evidenceEvaluating patientsACTA2 gene
2020
Multiple Cerebrovascular Insults in Pseudoxanthoma Elasticum
Sunmonu N. Multiple Cerebrovascular Insults in Pseudoxanthoma Elasticum. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105524. PMID: 33360520, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105524.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyPatients of European ancestryClinically significant haemorrhageSystemic genetic disordersRight internal carotid arteryIschaemic cerebral infarctionIncreased risk of GIRisk of ischaemic strokeHistory of GIInternal carotid arteryRisk of GIHaemorrhagic strokeSecondary stroke preventionRetinal bleedingVascular risk factorsVariable presentationPseudoxanthoma elasticumQuality of lifeSignificant haemorrhageNo historyIncreased riskCerebrovascular insultCerebral infarctionCarotid arteryPrimary disorderA Global First: Assessment of Sleep Apnoea and Select Sleep Disorders in an African Cohort (5528)
Sunmonu N, Akinyemi R, Owolabi M, Solenski N, Worrall B. A Global First: Assessment of Sleep Apnoea and Select Sleep Disorders in an African Cohort (5528). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.5528.Peer-Reviewed Original Research