IRS-2 pathways integrate female reproduction and energy homeostasis
Burks D, de Mora J, Schubert M, Withers D, Myers M, Towery H, Altamuro S, Flint C, White M. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000, 407: 377-382. PMID: 11014193, DOI: 10.1038/35030105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnergy IntakeEnergy MetabolismEstrusFemaleFertilityGonadal Steroid HormonesHomeostasisInfertilityInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLeptinLuteinizing HormoneMaleMiceMice, Inbred C57BLMice, KnockoutOvaryPhosphoproteinsPituitary GlandReceptor, InsulinReproductionSignal TransductionSteroidsConceptsInsulin receptor substrate 2Insulin/insulin-like growth factor-1Insulin-signaling pathwayEnergy homeostasisC. elegansIRS-2 pathwayLower organismsSubstrate 2Female reproductionRegulation of fertilityMetabolic signalsInsulin-like growth factor-1Reproductive statusFactor 1Infertile conditionsSevere dietary restrictionMammalsGrowth factor-1HomeostasisReproductionAnovulatory ovariesHypothalamic controlFemale infertilityPlasma concentrationsCatabolic state