Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes.
Bektas A, Warram J, White M, Krolewski A, Doria A. Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes 1999, 48: 640-642. PMID: 10078569, DOI: 10.2337/diabetes.48.3.640.Peer-Reviewed Original ResearchAdultAge of OnsetChromosome MappingChromosomes, Human, Pair 13Diabetes Mellitus, Type 2Diabetes, GestationalFemaleGenes, DominantGenetic LinkageGenetic MarkersGlucose IntoleranceHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLod ScoreMalePhosphoproteinsPregnancyReceptor, InsulinReference ValuesEarly biochemical events in insulin-stimulated fluid phase endocytosis
Pitterle D, Sperling R, Myers M, White M, Blackshear P. Early biochemical events in insulin-stimulated fluid phase endocytosis. American Journal Of Physiology 1999, 276: e94-e105. PMID: 9886955, DOI: 10.1152/ajpendo.1999.276.1.e94.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Fluid-phase endocytosisMitogen-activated protein kinase kinaseRat-1 cellsInsulin receptorDominant negative mutant RasHematopoietic precursor cell lineBat cellsHIRc-B cellsInhibitor of PIProtein kinase kinaseWild-type RasMEK inhibitor PD 98059Active insulin receptorEndogenous IRS-1Receptor substrate-1Inhibitor PD 98059Certain cell typesPrecursor cell lineInitial molecular mechanismsIRS-1 expressionKinase kinaseEarly biochemical eventsMutant RasSubstrate-1