2016
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase*
Copps K, Hançer N, Qiu W, White M. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase*. Journal Of Biological Chemistry 2016, 291: 8602-8617. PMID: 26846849, PMCID: PMC4861431, DOI: 10.1074/jbc.m116.714915.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsCHO CellsCricetinaeCricetulusGene DeletionGlucose IntoleranceInsulinInsulin Receptor Substrate ProteinsLiverMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMultiprotein ComplexesMutation, MissensePhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktRibosomal Protein S6 KinasesSerineSignal TransductionTOR Serine-Threonine KinasesTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsConceptsInsulin receptor substrate-1Receptor substrate-1PI3K associationS6 kinaseSubstrate-1Insulin-stimulated Akt activityAkt phosphorylationK associationRapamycin complex 1S6K signalingInsulin-stimulated IRS1 tyrosine phosphorylationSer-302IRS1 tyrosine phosphorylationMTORC1 inhibitor rapamycinRibosomal S6 proteinTsc1 deletionFeedback phosphorylationIntracellular amino acidsInsulin sensitivityTyrosine phosphorylationAlanine mutationsS6 proteinS6KAkt activityInsulin signaling
2013
IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance
Herrema H, Lee J, Zhou Y, Copps K, White M, Ozcan U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochemical And Biophysical Research Communications 2013, 443: 689-693. PMID: 24333417, PMCID: PMC3926104, DOI: 10.1016/j.bbrc.2013.12.023.Peer-Reviewed Original ResearchConceptsInsulin resistanceGlucose intoleranceInsulin sensitivityImpaired insulin receptorStress-induced insulin resistanceRapamycin complex 1 (mTORC1) activityPhosphorylation of IRS1Endoplasmic reticulum stressDiabetic miceER stress-induced insulin resistanceMammalian targetIRS1 phosphorylationReticulum stressMiceIntoleranceInsulin receptorVivoSer307
2004
Signaling Pathways: The Benefits of Good Communication
Fisher T, White M. Signaling Pathways: The Benefits of Good Communication. Current Biology 2004, 14: r1005-r1007. PMID: 15589136, DOI: 10.1016/j.cub.2004.11.024.Peer-Reviewed Original Research