1999
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Cousin S, Hügl S, Myers M, White M, Reifel-Miller A, Rhodes C. Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochemical Journal 1999, 344 Pt 3: 649-58. PMID: 10585851, PMCID: PMC1220686, DOI: 10.1042/0264-6021:3440649.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsCell DivisionCell LineDNA-Binding ProteinsGlucoseGRB2 Adaptor ProteinGrowth HormoneInsulin Receptor Substrate ProteinsInsulin-Like Growth Factor IIntracellular Signaling Peptides and ProteinsIslets of LangerhansJanus Kinase 2Milk ProteinsMitogen-Activated Protein KinasesPhosphoproteinsPhosphorylationProteinsProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsRibosomal Protein S6 KinasesShc Signaling Adaptor ProteinsSignal TransductionSon of Sevenless Protein, DrosophilaSrc Homology 2 Domain-Containing, Transforming Protein 1STAT5 Transcription FactorTrans-ActivatorsConceptsINS-1 cell proliferationSignal transduction pathwaysSignal transductionCell proliferationKinase 2Sevenless-1 proteinMitogenic signal transduction pathwaysJAK2/STAT5 pathwayMitogen-activated protein kinaseInsulin receptor substrateBeta-cell proliferationRat growth hormoneJAK2/STAT5Pancreatic beta cell proliferationMitogenic signalingS6 kinaseProtein kinaseProtein associationTranscription 5Beta-cell lineReceptor substrateDifferent mitogenicRat beta-cell lineDownstream activationIRS-2
1997
Interaction of p59fynwith Interferon-Activated Jak Kinases
Uddin S, Sher D, Alsayed Y, Pons S, Colamonici O, Fish E, White M, Platanias L. Interaction of p59fynwith Interferon-Activated Jak Kinases. Biochemical And Biophysical Research Communications 1997, 235: 83-88. PMID: 9196040, DOI: 10.1006/bbrc.1997.6741.Peer-Reviewed Original ResearchAntibodies, MonoclonalBlotting, WesternGlutathione TransferaseHumansInterferon Type IInterferon-gammaJanus Kinase 1Janus Kinase 2PhosphotyrosineProteinsProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-cblProto-Oncogene Proteins c-fynRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionSrc Homology DomainsTumor Cells, CulturedTYK2 KinaseUbiquitin-Protein Ligases
1996
Cross-talk between the insulin and angiotensin signaling systems.
Velloso L, Folli F, Sun X, White M, Saad M, Kahn C. Cross-talk between the insulin and angiotensin signaling systems. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 12490-12495. PMID: 8901609, PMCID: PMC38019, DOI: 10.1073/pnas.93.22.12490.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsElectrophoresis, Polyacrylamide GelInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsJanus Kinase 1Janus Kinase 2Janus Kinase 3MalePhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Protein-Tyrosine KinasesProto-Oncogene ProteinsRatsRats, WistarSignal TransductionTyrosineConceptsAngiotensin IIInjection of ANGIIEffect of AIIIRS-1/IRSAT1 receptor antagonistInsulin receptorRenal functionAT1 receptorInsulin resistanceReceptor antagonistCardiovascular diseaseAII stimulationAcute inhibitionIRS phosphorylationTyrosine phosphorylationReceptorsIRS-2Insulin-stimulated PIIRS-1G proteinsJAK2 tyrosine kinaseImportant regulatorInsulinRapid tyrosine phosphorylationTyrosine kinase