2018
Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization
Xi G, Shen X, Wai C, White M, Clemmons D. Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization. Journal Of Biological Chemistry 2018, 294: 2407-2421. PMID: 30578299, PMCID: PMC6378959, DOI: 10.1074/jbc.ra118.005398.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCell DifferentiationHumansHyperglycemiaInsulin Receptor Substrate ProteinsInsulin ResistanceKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceMice, KnockoutMultiprotein ComplexesMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein StabilityProto-Oncogene MasProto-Oncogene Proteins c-mdm2SwineTumor Suppressor Protein p53ConceptsKrüppel-like factor 4Vascular smooth muscle cell dedifferentiationSmooth muscle cell dedifferentiationInsulin receptor substrate-1Muscle cell dedifferentiationNormoglycemic miceAtherosclerotic lesionsHigh glucoseVSMC differentiationInsulin resistance stateP53 levelsIRS-1 knockdownSmooth muscle protein 22P53 associationExpression of p21Cell dedifferentiationMarker protein expressionAccelerates AtherosclerosisNondiabetic pigsDiabetic pigsIRS-1 overexpressionNutlin-3 treatmentMDM2/p53Receptor substrate-1MDM2 proto-oncogene
2007
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice.
Gonzalez-Navarro H, Vila-Caballer M, Pastor M, Vinue A, White M, Burks D, Andres V. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Frontiers In Bioscience-Landmark 2007, 12: 2291-8. PMID: 17127239, DOI: 10.2741/2231.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtherosclerosisBlood GlucoseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleHypercholesterolemiaInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLipidsMacrophagesMaleMiceMice, KnockoutMuscle, Smooth, VascularPhosphoproteinsConceptsInsulin receptor substrate 2ApoE-/- miceDevelopment of atherosclerosisIrs2-/- miceSevere hypercholesterolemiaInsulin levelsType 2 diabetic patientsAtherosclerotic lesion burdenPre-diabetic patientsPlasma insulin levelsFat-fed miceAbsence of hyperglycaemiaDefective insulin signalingDiabetic patientsLesion burdenClinical manifestationsInsulin resistanceModerate hypercholesterolemiaApolipoprotein EGlucose levelsAtherosclerotic lesionsAtherosclerosisHypercholesterolemiaNull miceImportant modulator