2004
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
Fujii N, Boppart M, Dufresne S, Crowley P, Jozsi A, Sakamoto K, Yu H, Aschenbach W, Kim S, Miyazaki H, Rui L, White M, Hirshman M, Goodyear L. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. American Journal Of Physiology - Cell Physiology 2004, 287: c200-c208. PMID: 15013949, DOI: 10.1152/ajpcell.00415.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDown-RegulationElectroporationEnzyme ActivationGene Transfer TechniquesGlycogen SynthaseHumansInjections, IntramuscularInsulin Receptor Substrate ProteinsMiceMice, KnockoutMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesMuscle ContractionMuscle ProteinsMuscle, SkeletalPhosphoproteinsPhosphorylationSerineTyrosineConceptsGlycogen synthase activityMouse skeletal muscleS6 kinasePhosphorylation stateJNK signalingSynthase activityJNK activityProtein kinase B/AktJNK overexpressionGlycogen synthase kinase-3Skeletal muscleExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2P70 S6 kinaseInsulin-stimulated glycogen synthase activitySynthase kinase-3P90 S6 kinaseBasal phosphorylation stateGlycogen synthase activationSitu muscle contractionBiological functionsTerminal kinaseKinase 3JNK activationKinase 1/2
2002
c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade*
Lee Y, Giraud J, Davis R, White M. c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade*. Journal Of Biological Chemistry 2002, 278: 2896-2902. PMID: 12417588, DOI: 10.1074/jbc.m208359200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesCell LineConsensus SequenceCulture Media, ConditionedHumansInsulinInsulin Receptor Substrate ProteinsJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesMolecular Sequence DataPhosphoproteinsPhosphorylationRatsSignal TransductionTransfectionConceptsC-Jun N-terminal kinaseN-terminal kinaseDirect bindingInsulin-stimulated tyrosine phosphorylationInsulin receptor substrate-1Interaction of JNKInsulin Signaling CascadeReceptor substrate-1Mouse embryo fibroblastsActivation of JNKFeedback inhibitionNegative feedback regulatorPhosphorylation of IRS1Cellular proteinsCell-permeable peptideTyrosine phosphorylationInsulin signalSignaling cascadesIRS1 proteinJNK activitySubstrate-1Insulin stimulationEmbryo fibroblastsPhosphorylationAkt phosphorylation