1998
Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians.
Bernal D, Almind K, Yenush L, Ayoub M, Zhang Y, Rosshani L, Larsson C, Pedersen O, White M. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians. Diabetes 1998, 47: 976-979. PMID: 9604879, DOI: 10.2337/diabetes.47.6.976.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceDiabetes Mellitus, Type 2ExonsFemaleFetusGene Expression RegulationHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsMaleMolecular Sequence DataOrgan SpecificityPhosphoproteinsPolymorphism, GeneticReceptor, InsulinRNA, MessengerSequence AlignmentSequence Homology, Amino AcidTranscription, GeneticWhite People
1996
Insulin Signal Transduction and the IRS Proteins
Myers M, White M. Insulin Signal Transduction and the IRS Proteins. The Annual Review Of Pharmacology And Toxicology 1996, 36: 615-658. PMID: 8725404, DOI: 10.1146/annurev.pa.36.040196.003151.Peer-Reviewed Original ResearchConceptsIRS proteinsIntracellular tyrosine kinaseBinding of SH2Numerous intracellular signalsTyrosine phosphorylation sitesReceptor-mediated phosphorylationInsulin signal transductionPTB domainCellular physiologyPhosphorylation sitesSignal transductionIntracellular signalsExtracellular domainTyrosine kinaseCytokine receptorsBiochemical eventsInsulin receptorGlucose transportProteinPhosphorylationSignalingGrowth factorSpecific receptorsExciting moleculesPropagation of signals