2001
Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome
El Mkadem S, Lautier C, Macari F, Molinari N, Lefèbvre P, Renard E, Gris J, Cros G, Daurès J, Bringer J, White M, Grigorescu F. Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome. Diabetes 2001, 50: 2164-2168. PMID: 11522686, DOI: 10.2337/diabetes.50.9.2164.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin resistanceIRS-1 variantOvary syndromeInsulin-resistant patientsIRS-2Severe insulin resistanceIRS-1IRS-2 geneControl subjectsPlasma glucoseInsulin receptor substrateWild-type variantMultivariate modelInsulin receptorNovel mutationsDirect sequencingGene dosage effectReceptor substrateSyndromeVariable degreesFunctional impactWomenPolymorphic allelesGly972Arg
1999
Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes.
Bektas A, Warram J, White M, Krolewski A, Doria A. Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes 1999, 48: 640-642. PMID: 10078569, DOI: 10.2337/diabetes.48.3.640.Peer-Reviewed Original ResearchAdultAge of OnsetChromosome MappingChromosomes, Human, Pair 13Diabetes Mellitus, Type 2Diabetes, GestationalFemaleGenes, DominantGenetic LinkageGenetic MarkersGlucose IntoleranceHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLod ScoreMalePhosphoproteinsPregnancyReceptor, InsulinReference Values