2000
Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B POSSIBLE FACILITATION BY THE FORMATION OF A TERNARY COMPLEX WITH THE GRB2 ADAPTOR PROTEIN*
Goldstein B, Bittner-Kowalczyk A, White M, Harbeck M. Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B POSSIBLE FACILITATION BY THE FORMATION OF A TERNARY COMPLEX WITH THE GRB2 ADAPTOR PROTEIN*. Journal Of Biological Chemistry 2000, 275: 4283-4289. PMID: 10660596, DOI: 10.1074/jbc.275.6.4283.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Receptor substrate-1Tyrosine dephosphorylationAdaptor proteinSubstrate-1Tyrosine-phosphorylated IRS-1Src homology 2 domainSteady-state tyrosine phosphorylationAdaptor protein Grb2Grb2 adaptor proteinStable protein complexesProtein tyrosine phosphataseNovel molecular interactionInsulin signal transductionMolecular interactionsProtein Grb2Protein complexesP85 subunitSHP-2Overlay blotsP-nitrophenyl phosphateSignal transductionTyrosine phosphorylationPhosphorylation stateInactive PTP1B
1998
A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Schuppin G, Pons S, Hügl S, Aiello L, King G, White M, Rhodes C. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes 1998, 47: 1074-1085. PMID: 9648831, DOI: 10.2337/diabetes.47.7.1074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBloodCell DifferentiationCell DivisionDNAGene ExpressionGenes, fosGenes, junInsulin Receptor Substrate ProteinsInsulinomaIntracellular Signaling Peptides and ProteinsIslets of LangerhansMitogensMolecular Sequence DataPancreatic NeoplasmsPhosphoproteinsRatsRetroelementsRNA, MessengerSignal TransductionTumor Cells, CulturedConceptsSignal transduction pathwaysIRS-2 expressionPancreatic beta-cell lineIRS-2Protein kinaseTransduction pathwaysBeta-cell lineGene expressionIRS-2 gene expressionSevenless-1 proteinBeta-cell growthDifferential mRNA display analysisMitogen-activated protein kinaseDifferential gene expressionTyrosine protein kinaseInsulin receptor substrate 2Insulinoma cellsInsulin receptor substrateGene candidate approachSerum-stimulated DNA synthesisPancreatic beta-cell growthRibosomal proteinsProtein complexesMRNA levelsBeta-cells contributes