Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor*
Sawka-Verhelle D, Baron V, Mothe I, Filloux C, White M, Van Obberghen E. Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor*. Journal Of Biological Chemistry 1997, 272: 16414-16420. PMID: 9195949, DOI: 10.1074/jbc.272.26.16414.Peer-Reviewed Original ResearchConceptsInsulin receptorIRS-2Tyrosine residuesPleckstrin homology domainPeptide competition studiesInsulin receptor substrateAmino acids 591Homology domainReceptor substrateBinding domainsRegulatory loopIRS-1Novel mechanismPosition 624ResiduesCompetition studiesReceptorsDomainIts AssociationPhosphotyrosinePhosphorylationBindsBindingRegionInteraction