Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
Rhodes C, White M, Leahy J, Kahn S. Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense? Diabetes 2013, 62: 2157-2163. PMID: 23801714, PMCID: PMC3712043, DOI: 10.2337/db13-0246.Peer-Reviewed Original ResearchConceptsΒ-cellsDirect autocrine effectsTransgenic mouse studiesSignal transductionPancreatic β-cellsDownstream elementsAutocrine actionRelevant ligandsΒ-cell functionAutocrine effectsMouse studiesCircumstantial evidencePhysiological senseTransductionAvailable experimental evidencePathwayInsightsExperimental evidenceInsulin