2011
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Kelley G, Dong X, Krainc D, White M. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. Journal Of Clinical Investigation 2011, 121: 4070-4081. PMID: 21926467, PMCID: PMC3195462, DOI: 10.1172/jci46305.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBrainDisease Models, AnimalDisease ProgressionFemaleForkhead Box Protein O1Forkhead Transcription FactorsGene ExpressionHumansHuntington DiseaseInsulin Receptor Substrate ProteinsLongevityMaleMiceMice, KnockoutMice, Mutant StrainsMice, TransgenicMitochondriaOxidative StressSignal TransductionConceptsHuntington's diseaseOxidative stressMouse modelProgression of HDMitochondrial dysfunctionMajor risk factorR6/2 mouse modelNeuronal oxidative stressMitochondrial functionHD-like symptomsHD patientsNumber of autophagosomesTranscription factor FOXO1Risk factorsR6/2 miceSlow progressionTherapeutic approachesExpression of IRS2HD progressionLife spanNeurodegenerative diseasesIRS2 levelsProgressionDiseaseMice
2010
Insulin signaling meets mitochondria in metabolism
Cheng Z, Tseng Y, White M. Insulin signaling meets mitochondria in metabolism. Trends In Endocrinology And Metabolism 2010, 21: 589-598. PMID: 20638297, PMCID: PMC3994704, DOI: 10.1016/j.tem.2010.06.005.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseSirt1/PGC1α pathwayMitochondria generateRedox regulationTyrosine phosphataseIRS-PI3KMetabolic platformMitochondrial metabolismHigh ROS levelsMitochondrial biogenesisMolecular linkMitochondrial functionInsulin receptorMetabolic homeostasisMitochondrial dysfunctionROS levelsOxygen speciesMitochondriaInsulin actionMechanistic associationRecent studiesMetabolismMetabolic diseasesBiogenesisChain integrity
2009
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers J, Depinho R, Puigserver P, White M. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine 2009, 15: 1307-1311. PMID: 19838201, PMCID: PMC3994712, DOI: 10.1038/nm.2049.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCells, CulturedElectron Transport Chain Complex ProteinsForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationHeme Oxygenase-1HepatocytesInsulinInsulin Receptor Substrate ProteinsLiverMembrane Potential, MitochondrialMembrane ProteinsMiceMice, KnockoutMicroscopy, Electron, TransmissionMitochondriaMutationNADPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSignal TransductionTrans-ActivatorsTranscription Factors