2013
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
Sadagurski M, Dong X, Myers M, White M. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism 2013, 3: 55-63. PMID: 24567904, PMCID: PMC3929908, DOI: 10.1016/j.molmet.2013.10.004.Peer-Reviewed Original ResearchFed blood glucose levelsBlood glucose levelsLepRb neuronsSevere obesityInsulin resistanceInsulin receptor substrateGlucose levelsLeptin receptorGlucose homeostasisBody weightInsulin/IGF1MiceMetabolic homeostasisEnergy expenditureNeuronsWhole bodyReceptor substrateIRS2Metabolic sensingHomeostasisMetabolic regulationHyperglycemiaLepRbObesityHypothalamus
2012
Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling
Sadagurski M, White M. Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling. Endocrinology And Metabolism Clinics Of North America 2012, 42: 127-148. PMID: 23391244, PMCID: PMC3982789, DOI: 10.1016/j.ecl.2012.11.008.Peer-Reviewed Original ResearchConceptsInsulin/IGF1Central nervous systemLife spanOrganism longevityCellular functionsStress resistanceGenetic manipulationIGF1 signalingInsulin pathwayMetabolic homeostasisEnergy homeostasisPeripheral energy homeostasisSystemic insulin resistanceHomeostasisMetabolismSystemic metabolismNeuronal circuitsCompensatory hyperinsulinemiaInsulin resistanceIGF1Central regulationExcess insulinNervous systemLongevityNematodes
2011
Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
Long Y, Cheng Z, Copps K, White M. Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways. Molecular And Cellular Biology 2011, 31: 430-441. PMID: 21135130, PMCID: PMC3028618, DOI: 10.1128/mcb.00983-10.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsBody CompositionBody WeightEnzyme ActivationForkhead Transcription FactorsGlucoseHomeostasisIn Vitro TechniquesInsulinInsulin Receptor Substrate ProteinsLactic AcidMiceMice, KnockoutModels, BiologicalMuscle, SkeletalMyocardiumOrgan SizeOrgan SpecificityProto-Oncogene Proteins c-aktSignal TransductionUp-RegulationConceptsSkeletal muscle growthMdKO miceMuscle growthElevated AMP/ATP ratioInsulin-receptor substrate IRS1AMP/ATP ratioSkeletal muscleInsulin receptor substrateMuscle creatine kinaseSubstrates IRS1Insulin-stimulated glucose uptakeProtein kinaseNutrient availabilityReceptor substrateCarboxylase phosphorylationFatty acid oxidationAMPK pathwayMetabolic homeostasisATP ratioIRS1Impaired growthKinaseAmino acid releaseSkeletal muscle massAtrogene expression
2010
Insulin signaling meets mitochondria in metabolism
Cheng Z, Tseng Y, White M. Insulin signaling meets mitochondria in metabolism. Trends In Endocrinology And Metabolism 2010, 21: 589-598. PMID: 20638297, PMCID: PMC3994704, DOI: 10.1016/j.tem.2010.06.005.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseSirt1/PGC1α pathwayMitochondria generateRedox regulationTyrosine phosphataseIRS-PI3KMetabolic platformMitochondrial metabolismHigh ROS levelsMitochondrial biogenesisMolecular linkMitochondrial functionInsulin receptorMetabolic homeostasisMitochondrial dysfunctionROS levelsOxygen speciesMitochondriaInsulin actionMechanistic associationRecent studiesMetabolismMetabolic diseasesBiogenesisChain integrity