Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models
Cheng Z, White M. Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models. Antioxidants & Redox Signaling 2010, 14: 649-661. PMID: 20615072, PMCID: PMC3025764, DOI: 10.1089/ars.2010.3370.Peer-Reviewed Original ResearchConceptsForkhead box O (FOXO) transcription factorsInsulin receptor substratePhosphoenolpyruvate carboxykinaseActivation of FOXO1Β-cellsRegulation of metabolismAkt signal cascadeRole of FoxO1Transcriptional regulationForkhead box O1Β-cell proliferationStress resistanceTranscription factorsDuodenal homeobox 1Mitochondrial metabolismPancreatic β-cellsReceptor substrateSignal cascadeΒ-cell failureLipid switchesCarboxypeptidase E.Mouse modelHomeobox 1Metabolic diseasesInhibition of FOXO1