IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance
Herrema H, Lee J, Zhou Y, Copps K, White M, Ozcan U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochemical And Biophysical Research Communications 2013, 443: 689-693. PMID: 24333417, PMCID: PMC3926104, DOI: 10.1016/j.bbrc.2013.12.023.Peer-Reviewed Original ResearchConceptsInsulin resistanceGlucose intoleranceInsulin sensitivityImpaired insulin receptorStress-induced insulin resistanceRapamycin complex 1 (mTORC1) activityPhosphorylation of IRS1Endoplasmic reticulum stressDiabetic miceER stress-induced insulin resistanceMammalian targetIRS1 phosphorylationReticulum stressMiceIntoleranceInsulin receptorVivoSer307