2004
IRS‐2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes
Valverde A, Fabregat I, Burks D, White M, Benito M. IRS‐2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology 2004, 40: 1285-1294. PMID: 15565601, DOI: 10.1002/hep.20485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisApoptosis Regulatory ProteinsBcl-2-Like Protein 11Bcl-X ProteinBlood ProteinsCarrier ProteinsEpidermal Growth FactorFemaleForkhead Box Protein O1Forkhead Transcription FactorsGene ExpressionHepatocytesHypoglycemic AgentsInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, Mutant StrainsPhosphatidylinositol 3-KinasesPhosphoproteinsPregnancyProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Signal TransductionTranscription FactorsConceptsCaspase-3 activityIRS-2Caspase-3 activationGene expressionWild-type hepatocytesDominant negative FoxO1Wild-type cellsSerum withdrawal-induced apoptosisInsulin receptor substrateWithdrawal-induced apoptosisAnti-apoptotic gene expressionImmortalized hepatocyte cell linesIRS-2 signalingPIP3 generationProapoptotic gene expressionAntiapoptotic gene expressionProlonged insulin treatmentEpidermal growth factorActive FoxO1Receptor substrateNeonatal hepatocytesProapoptotic genesAntiapoptotic genesCaspase-8Serum withdrawal
2002
IRS proteins and the common path to diabetes
White M. IRS proteins and the common path to diabetes. AJP Endocrinology And Metabolism 2002, 283: e413-e422. PMID: 12169433, DOI: 10.1152/ajpendo.00514.2001.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate (IRS) proteinsIRS protein functionsProteosome-mediated degradationCommon regulatory pathwayCommon molecular mechanismIntracellular signaling cascadesInsulin/IGF receptorIRS-2 signalingCell surface receptorsIRS proteinsSubstrate proteinsPancreatic beta-cell growthProtein functionGrowth factor actionNutrient sensingSerine phosphorylationRegulatory pathwaysSignaling cascadesIGF-signaling pathwayInsulin resistanceMolecular mechanismsIRS-2Insulin-like growth factor actionIRS-1Broader roleInsulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice
Howlett K, Sakamoto K, Hirshman M, Aschenbach W, Dow M, White M, Goodyear L. Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice. Diabetes 2002, 51: 479-483. PMID: 11812758, DOI: 10.2337/diabetes.51.2.479.Peer-Reviewed Original ResearchConceptsPhosphotyrosine-associated phosphatidylinositolIRS-2 tyrosine phosphorylationIRS-2 signalingInsulin receptor substrate-2-deficient (IRS2(-/-)) miceWild-type miceIRS-2-deficient miceEnhanced insulin actionWT miceTyrosine phosphorylationTreadmill exerciseInsulin receptor substrateInsulin actionMiceImmediate periodSkeletal muscleInsulin-stimulated responsesInsulin signalingMarked increaseReceptor substrateExerciseInsulinPresent studySignalingPhosphorylation