Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome
El Mkadem S, Lautier C, Macari F, Molinari N, Lefèbvre P, Renard E, Gris J, Cros G, Daurès J, Bringer J, White M, Grigorescu F. Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome. Diabetes 2001, 50: 2164-2168. PMID: 11522686, DOI: 10.2337/diabetes.50.9.2164.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin resistanceIRS-1 variantOvary syndromeInsulin-resistant patientsIRS-2Severe insulin resistanceIRS-1IRS-2 geneControl subjectsPlasma glucoseInsulin receptor substrateWild-type variantMultivariate modelInsulin receptorNovel mutationsDirect sequencingGene dosage effectReceptor substrateSyndromeVariable degreesFunctional impactWomenPolymorphic allelesGly972Arg