2012
Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes
Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan M, Adam R, White M, Olumi A. Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Diabetes 2012, 61: 2134-2145. PMID: 22688336, PMCID: PMC3402324, DOI: 10.2337/db11-1763.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2Disease Models, AnimalInsulin Receptor Substrate ProteinsMetforminMiceMice, KnockoutMuscle ContractionMyosin Light ChainsReceptors, Tumor Necrosis Factor, Type IRho-Associated KinasesTumor Necrosis Factor-alphaUp-RegulationUrinary BladderUrinary Bladder DiseasesUrinary Bladder, OveractiveConceptsDiabetic bladder dysfunctionTumor necrosis factorType 2 diabetesBladder dysfunctionDKO animalsPrimary cultured bladder smooth muscle cellsSoluble TNF receptor 1Bladder smooth muscle tissueInhibition of TNFCultured bladder smooth muscle cellsAppropriate animal modelsBladder smooth muscle cellsTNF receptor 1Smooth muscle cellsRho-kinase activitySmooth muscle tissueInsulin receptor substrate-1Detrusor hypoactivityUrologic complicationsDetrusor overactivitySystemic treatmentDiabetic patientsClinical featuresBladder fillingVoided volume
2007
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice.
Gonzalez-Navarro H, Vila-Caballer M, Pastor M, Vinue A, White M, Burks D, Andres V. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Frontiers In Bioscience-Landmark 2007, 12: 2291-8. PMID: 17127239, DOI: 10.2741/2231.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtherosclerosisBlood GlucoseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleHypercholesterolemiaInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLipidsMacrophagesMaleMiceMice, KnockoutMuscle, Smooth, VascularPhosphoproteinsConceptsInsulin receptor substrate 2ApoE-/- miceDevelopment of atherosclerosisIrs2-/- miceSevere hypercholesterolemiaInsulin levelsType 2 diabetic patientsAtherosclerotic lesion burdenPre-diabetic patientsPlasma insulin levelsFat-fed miceAbsence of hyperglycaemiaDefective insulin signalingDiabetic patientsLesion burdenClinical manifestationsInsulin resistanceModerate hypercholesterolemiaApolipoprotein EGlucose levelsAtherosclerotic lesionsAtherosclerosisHypercholesterolemiaNull miceImportant modulator
1999
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity
Almind K, Frederiksen S, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm C, Berglund L, Reneland R, Lithell H, White M, Van Obberghen E, Pedersen O. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia 1999, 42: 1244-1249. PMID: 10525667, DOI: 10.1007/s001250051299.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid SubstitutionBase SequenceDiabetes Mellitus, Type 2Gene FrequencyGenetic Carrier ScreeningGenetic TestingGlucose Tolerance TestHumansInsulinInsulin Receptor Substrate ProteinsInsulin SecretionIntracellular Signaling Peptides and ProteinsMaleMiddle AgedMolecular Sequence DataPedigreePhosphoproteinsPhosphotyrosinePolymorphism, Single-Stranded ConformationalPromoter Regions, GeneticProspective StudiesTwo-Hybrid System TechniquesConceptsType II diabetic patientsII diabetic patientsSerum insulin concentrationsInsulin secretionDiabetic patientsInsulin sensitivityInsulin concentrationsGly1057Asp variantInsulin receptor substrate-2 (IRS-2) geneIntravenous glucose tolerance testGlucose-tolerant offspringGlucose tolerance testGlucose-tolerant subjectsIRS-2Elderly Swedish menMiddle-aged subjectsYoung healthy subjectsAmino acid variantsWildtype carriersDiabetic parentsTolerance testTolerant subjectsHealthy subjectsStudy groupInsulin sensivity