Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes
Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan M, Adam R, White M, Olumi A. Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Diabetes 2012, 61: 2134-2145. PMID: 22688336, PMCID: PMC3402324, DOI: 10.2337/db11-1763.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2Disease Models, AnimalInsulin Receptor Substrate ProteinsMetforminMiceMice, KnockoutMuscle ContractionMyosin Light ChainsReceptors, Tumor Necrosis Factor, Type IRho-Associated KinasesTumor Necrosis Factor-alphaUp-RegulationUrinary BladderUrinary Bladder DiseasesUrinary Bladder, OveractiveConceptsDiabetic bladder dysfunctionTumor necrosis factorType 2 diabetesBladder dysfunctionDKO animalsPrimary cultured bladder smooth muscle cellsSoluble TNF receptor 1Bladder smooth muscle tissueInhibition of TNFCultured bladder smooth muscle cellsAppropriate animal modelsBladder smooth muscle cellsTNF receptor 1Smooth muscle cellsRho-kinase activitySmooth muscle tissueInsulin receptor substrate-1Detrusor hypoactivityUrologic complicationsDetrusor overactivitySystemic treatmentDiabetic patientsClinical featuresBladder fillingVoided volume