2010
Chapter 331 IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues
White M. Chapter 331 IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues. 2010, 2873-2883. DOI: 10.1016/b978-0-12-374145-5.00331-4.Peer-Reviewed Original ResearchInsulin-like growth factor signalsInsulin-like receptorGrowth factor signalsΒ-cell growthIRS proteinsNutrient homeostasisFactor signalsAdapter moleculeSystemic growthInsulin receptorSimilar signalingInsulin targetsRational platformCommon systemic disordersType 2 diabetesCascadePhysiologic roleInsulin actionInsulin resistanceSystemic disordersIGF actionInsulin responseInsulin secretionCardiovascular diseaseDiabetic tissues
2006
Regulating insulin signaling and -cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins12th International Conference.
White M. Regulating insulin signaling and -cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins12th International Conference. Canadian Journal Of Physiology And Pharmacology 2006, 84: 725-737. PMID: 16998536, DOI: 10.1139/y06-008.Peer-Reviewed Original ResearchConceptsType 2 diabetesInsulin resistanceBeta-cell destructionPeripheral insulin resistanceDiabetes mellitusChronic hyperglycemiaSystemic disordersFemale infertilityInsulin secretionCardiovascular diseaseCell functionInevitable progressionComplex disorderDisordersDiabetesGreater frequencyPrevalent formInsulinPhosphoproteins12th International ConferenceAgeSecond messengerDyslipidemiaHypertensionMellitusAutoimmune
1999
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Jiang Z, Lin Y, Clemont A, Feener E, Hein K, Igarashi M, Yamauchi T, White M, King G. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. Journal Of Clinical Investigation 1999, 104: 447-457. PMID: 10449437, PMCID: PMC408521, DOI: 10.1172/jci5971.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCalcium-Calmodulin-Dependent Protein KinasesIn Vitro TechniquesInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceIntracellular Signaling Peptides and ProteinsLiverMaleMicrocirculationObesityPhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationRatsRats, ZuckerReceptor, InsulinRecombinant ProteinsSignal TransductionTyrosineConceptsObese ratsLean ratsObese ZuckerIRS-2-associated PIIndependent risk factorProtein levelsEuglycemic clamp studiesInsulin-resistant statesObese Zucker ratsSelective resistanceTyrosine phosphorylationVascular tissueInsulin resistanceInsulin infusionRisk factorsCardiovascular diseaseClamp studiesZucker ratsReceptor beta subunitAortaRatsInsulinInsulin receptor beta subunitERK 1/2Vivo studies
1996
Cross-talk between the insulin and angiotensin signaling systems.
Velloso L, Folli F, Sun X, White M, Saad M, Kahn C. Cross-talk between the insulin and angiotensin signaling systems. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 12490-12495. PMID: 8901609, PMCID: PMC38019, DOI: 10.1073/pnas.93.22.12490.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsElectrophoresis, Polyacrylamide GelInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsJanus Kinase 1Janus Kinase 2Janus Kinase 3MalePhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Protein-Tyrosine KinasesProto-Oncogene ProteinsRatsRats, WistarSignal TransductionTyrosineConceptsAngiotensin IIInjection of ANGIIEffect of AIIIRS-1/IRSAT1 receptor antagonistInsulin receptorRenal functionAT1 receptorInsulin resistanceReceptor antagonistCardiovascular diseaseAII stimulationAcute inhibitionIRS phosphorylationTyrosine phosphorylationReceptorsIRS-2Insulin-stimulated PIIRS-1G proteinsJAK2 tyrosine kinaseImportant regulatorInsulinRapid tyrosine phosphorylationTyrosine kinase