Metabolic Dysfunction within Brown Adipose Tissue and Skeletal Muscle Caused by Complete Hepatic Insulin Resistance Is Reversible by FGF-21 Treatment
STOEHR O, TAO R, COPPS K, WHITE M. Metabolic Dysfunction within Brown Adipose Tissue and Skeletal Muscle Caused by Complete Hepatic Insulin Resistance Is Reversible by FGF-21 Treatment. Diabetes 2018, 67 DOI: 10.2337/db18-1873-p.Peer-Reviewed Original ResearchHepatic insulin resistanceFGF-21Insulin resistanceGlucose toleranceSkeletal muscleGlucose uptakeAdipose tissue markersFGF-21 treatmentSkeletal muscle dysfunctionSystemic insulin resistanceBetter glucose toleranceSystemic glucose homeostasisDouble knockout miceBrown adipose tissueDeletion of FoxO1Hepatokine secretionThermogenesis markersHepatic infectionBody core temperatureGlucose intoleranceMuscle dysfunctionSevere hyperglycemiaControl miceInsulin sensitivityMetabolic dysfunction