Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.
Delahaye L, Mothe-Satney I, Myers M, White M, Van Obberghen E. Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. Endocrinology 1998, 139: 4911-9. PMID: 9832428, DOI: 10.1210/endo.139.12.6379.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Protein kinase B activitySerine phosphorylation sitesRegulatory subunitReceptor substrate-1Phosphorylation sitesPotential binding sitesTyrosine phosphorylationSubstrate-1Potential tyrosine phosphorylation sitesIRS-1 interactsPotential serine phosphorylation sitesWild-type IRS-1Two-hybrid systemTyrosine phosphorylation sitesInsulin-stimulated phosphatidylinositolPhosphorylate IRS-1P85alpha regulatory subunitBinding sitesYeast kinasesThreonine phosphorylationSerine mutantsYXXM motifsB activityP85alphaInteraction of Insulin Receptor Substrate-1 (IRS-1) with Phosphatidylinositol 3-Kinase: Effect of Substitution of Serine for Alanine in Potential IRS-1 Serine Phosphorylation Sites
Delahaye L, Mothe-Satney I, Myers M, White M, Van Obberghen E. Interaction of Insulin Receptor Substrate-1 (IRS-1) with Phosphatidylinositol 3-Kinase: Effect of Substitution of Serine for Alanine in Potential IRS-1 Serine Phosphorylation Sites. Endocrinology 1998, 139: 4911-4919. DOI: 10.1210/en.139.12.4911.Peer-Reviewed Original ResearchInsulin receptor substrate-1Protein kinase B activationSerine phosphorylation sitesPI 3-kinaseRegulatory subunitPotential binding sitesPhosphorylation sitesTyrosine phosphorylationRegulatory subunit of PI 3-kinasePI 3-kinase regulatory subunitSubunit of PI 3-kinaseTyrosine phosphorylation of insulin receptor substrate-1Interaction of insulin receptor substrate-1Phosphorylation of insulin receptor substrate-1Yeast two-hybrid systemInsulin-stimulated PI 3-kinase activityWild-type IRS-1Potential serine phosphorylation sitesLevel of insulin receptor substrate-1PI 3-kinase activityRegulatory subunit of phosphatidylinositolPhosphorylated insulin receptor substrate-1Two-hybrid systemBinding sitesSubstitution of serine