2022
Journal Club: Neurofilament Light Chain Levels in Anti-NMDAR Encephalitis and Primary Psychiatric Psychosis
Deerhake M, Giarraputo J, Gupta M, Eckstein C. Journal Club: Neurofilament Light Chain Levels in Anti-NMDAR Encephalitis and Primary Psychiatric Psychosis. Neurology 2022, 99: 854-857. PMID: 36038273, PMCID: PMC9651450, DOI: 10.1212/wnl.0000000000201235.Peer-Reviewed Original ResearchConceptsNMDA receptor encephalitisAntibody testingNeurofilament light chain levelsAutoimmune brain disordersAnti-NMDAR encephalitisSubset of patientsPrimary psychiatric disordersLight chain levelsReceptor encephalitisLumbar punctureNMDA receptorsSerum testPsychiatric disordersBrain disordersClinical settingEncephalitisDisordersPatientsPuncturePsychosisCSFChain levelAntibodiesReceptors
2019
Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models
Deerhake ME, Biswas DD, Barclay WE, Shinohara ML. Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. Frontiers In Immunology 2019, 10: 2644. PMID: 31781124, PMCID: PMC6861384, DOI: 10.3389/fimmu.2019.02644.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPattern recognition receptorsMultiple sclerosisCNS autoimmunityAnimal modelsRecognition receptorsIts Animal ModelsNon-immune cellsInnate immune responseProtective functionFunction of PRRsPRR responsesAutoimmune encephalomyelitisImmune responseEndogenous ligandAutoimmunitySclerosisFurther investigationReceptorsDistinct triggersEncephalomyelitisResponse
2018
Are Neuropeptide-Reactive T Cells behind Narcolepsy?
Deerhake ME, Barclay WE, Shinohara ML. Are Neuropeptide-Reactive T Cells behind Narcolepsy? Immunity 2018, 49: 796-798. PMID: 30462995, DOI: 10.1016/j.immuni.2018.11.002.Peer-Reviewed Original Research
2012
Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites
Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, MacInnis B, Kwiatkowski DP, Conway DJ. Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites. PLOS Genetics 2012, 8: e1002992. PMID: 23133397, PMCID: PMC3486833, DOI: 10.1371/journal.pgen.1002992.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsPaired-end short-read sequencesHistorical population expansionPopulation genomic scansHuman malaria parasite Plasmodium falciparumMinority of genesMalaria parasite Plasmodium falciparumSite frequency spectrumPhase-variable expressionShort read sequencesParasite Plasmodium falciparumBalancing selectionGene familyGenomic scansReference genomeClonal parasite linesPopulation expansionSequence dataProtein productsParasite linesGenesMerozoite stageFunctional studiesSchizont stageNucleotide polymorphisms