2017
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks‐Kayal A, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 2017, 59: 37-66. PMID: 29247482, PMCID: PMC5993212, DOI: 10.1111/epi.13965.Peer-Reviewed Original ResearchConceptsAcute brain insultsAnimal modelsPrevention therapyBrain insultsBrain injuryInjury etiologyHuman epilepsyClinical testingCentral nervous system infectionFluid percussion injury modelTemporal lobe epilepsy patientsPost-status epilepticus modelDisease modification strategiesNervous system infectionMolecular targetsBetter patient selectionInflammatory cellular infiltrateLoss of neuronsWeeks of injuryBlood-brain barrierTraumatic brain injuryPreclinical animal modelsGap junction couplingCommon histopathologicEpilepsy prevention
2015
Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE)
Touloumes G, Morse E, Chen WC, Gober L, Dente J, Lilenbaum R, Katzenstein E, Pacelli A, Johnson E, Si Y, Sivaraju A, Grover E, Khozein R, Cunningham C, Hirsch LJ, Blumenfeld H. Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE). Epilepsia 2015, 57: e28-e32. PMID: 26663137, PMCID: PMC4707993, DOI: 10.1111/epi.13262.Peer-Reviewed Original ResearchConceptsVideo-EEG dataResponsiveness testingClinical careBehavioral testingInpatient video-electroencephalography (EEG) monitoringVideo-electroencephalography monitoringVideo-EEG monitoringAdditional clinical testingPediatric patientsEpilepsy centersPresurgical evaluationBedside evaluationClinical testingEpileptic seizuresBehavioral impairmentsSeizuresAccurate diagnosisNonmedical personnelPatient roomsEpilepsyBehavioral evaluationSeizure detectionBehavioral tasksMedical decisionsAutomatic seizure detection