1998
Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve
Yee J, Agulian S, Kocsis J. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy Research 1998, 29: 195-200. PMID: 9551781, DOI: 10.1016/s0920-1211(97)00086-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnticonvulsantsAstrocytesAxonsBicucullineCarrier ProteinsGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane PotentialsMembrane ProteinsMembrane Transport ProteinsModels, NeurologicalNipecotic AcidsOptic NerveOrganic Anion TransportersPotassium ChlorideProlineRatsRats, WistarReceptors, GABA-ATime FactorsVigabatrinConceptsRelease of GABAGABA levelsNipecotic acidNeonatal rat optic nerveGABA transporter inhibitorOptic nerve axonsRat optic nerveOptic nerve astrocytesEnzyme GABA transaminaseGABA transaminase activityFree GABA levelsOptic nerveAntiepileptic drugsNO-711GABA transporterNerve axonsTransaminase activityGABA transaminaseVigabatrinTransporter inhibitorsGABADepolarizationGreater releaseElevationRelease
1995
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis
Honmou O, Oyelese A, Kocsis J. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Research 1995, 692: 273-277. PMID: 8548315, DOI: 10.1016/0006-8993(95)00634-3.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsFree GABA levelsField potential analysisNipecotic acidGABA levelsPopulation excitatory postsynaptic potentialEffects of microapplicationRelease of GABAGABAA receptor activationAdult rat brainMechanism of actionGABA releasePartial seizuresAnticonvulsant gabapentinPresynaptic volleyPostsynaptic potentialsBath applicationHippocampal slicesRat brainGBP treatmentHippocampal cellsBlock uptakeGabapentinReceptor activationGABAGabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
Honmou O, Kocsis J, Richerson G. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Research 1995, 20: 193-202. PMID: 7796791, DOI: 10.1016/0920-1211(94)00076-9.Peer-Reviewed Original ResearchConceptsRelease of GABACA1 pyramidal neuronsNipecotic acidPyramidal neuronsGABAA receptorsWhole-cell patch-clamp recordingsGABA uptake systemRat optic nerveCalcium-free solutionPeriod of hyperexcitabilityPatch-clamp recordingsChloride equilibrium potentialMechanism of actionGabapentin exposurePartial seizuresPressure microejectionOptic nerveAnticonvulsant gabapentinNonvesicular releaseHippocampal slicesNeuronal inhibitionMetabolic effectsSynaptic transmissionWhole-cell conductanceClamp recordings
1994
Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve
Kocsis J, Honmou O. Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neuroscience Letters 1994, 169: 181-184. PMID: 8047279, DOI: 10.1016/0304-3940(94)90386-7.Peer-Reviewed Original Research
1993
The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve
Lim J, Utzschneider D, Sakatani K, Kocsis J. The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve. Brain Research 1993, 72: 15-20. PMID: 8384095, DOI: 10.1016/0165-3806(93)90155-4.Peer-Reviewed Original ResearchConceptsOptic nerveRat optic nerveEffect of GABAMD ratsNipecotic acidGABA sensitivityGABA uptake inhibitor nipecotic acidNormal optic nervesGABAA receptor agonistOptic nerve axonsEarly postnatal periodCentral nervous system axonsThird postnatal weekSucrose gap techniqueResult of myelinationLarger GABAAxonal excitabilityControl ratsGABAA receptorsEndogenous releasePostnatal periodPostnatal weekNerve sensitivityNerveGABA
1992
Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve
Sakatani K, Black J, Kocsis J. Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve. Proceedings Of The Royal Society B 1992, 247: 155-161. PMID: 1349183, DOI: 10.1098/rspb.1992.0022.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveCentral nervous systemGABAA receptorsIntact rat optic nerveCultured glia cellsFunctional GABAA receptorsGABAA receptor agonistNeonatal optic nerveNeuronal cell bodiesO-2A progenitor cellsNon-synaptic sitesPre-myelinated axonsWhite matter regionsSynthesis of GABAAxonal excitabilityReceptor agonistEndogenous GABAGABA uptakeGlia cellsSynaptic neurotransmittersNervous systemEndogenous neurotransmittersType 2Nerve