Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia
Kenney A, Kocsis J. Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia. Brain Research 1997, 52: 53-61. PMID: 9450677, DOI: 10.1016/s0169-328x(97)00211-8.Peer-Reviewed Original ResearchConceptsDorsal root gangliaDorsal root transectionPeripheral axotomyDRG neuronsRoot transectionRoot gangliaProtein levelsAdult rat lumbar dorsal root gangliaRat lumbar dorsal root gangliaLumbar dorsal root gangliaAdult rat dorsal root gangliaRat dorsal root gangliaNeurotrophic factor administrationSpinal nerve transectionC-Jun protein levelsAdministration of NGFFactor protein levelsJunD protein levelsTarget disconnectionNerve transectionFactor administrationPeripheral branchesTransectionFactor levelsRapid elevationDifferential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons
Oyelese A, Rizzo M, Waxman S, Kocsis J. Differential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 1997, 78: 31-42. PMID: 9242258, PMCID: PMC2605357, DOI: 10.1152/jn.1997.78.1.31.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorCutaneous afferent neuronsNerve growth factorReceptor-mediated conductanceProportion of neuronsAfferent neuronsAction potential waveformSodium currentNeurotrophic factorL4/L5 DRG neuronsAction potentialsVoltage-dependent sodium currentsWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCell patch-clamp techniqueAxotomy-induced increaseFluoro-Gold injectionsL5 DRG neuronsSpecific neurotrophic factorsSciatic nerve stumpsTTX-sensitive currentsInjury-induced changesResistant sodium currentsGamma-aminobutyric acidPatch-clamp technique