1994
Intracellular calcium mobilization and neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Intracellular calcium mobilization and neurite outgrowth in mammalian neurons. Developmental Neurobiology 1994, 25: 252-264. PMID: 8195789, DOI: 10.1002/neu.480250306.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCaffeineCalciumCalcium ChannelsCell CompartmentationCell DifferentiationCells, CulturedFemaleGanglia, SpinalGene Expression RegulationImage Processing, Computer-AssistedIntracellular FluidIon Channel GatingLasersMicroscopy, FluorescenceModels, BiologicalNeuritesNeuronsRatsRats, WistarTerpenesThapsigarginConceptsDepolarization-induced Ca2Calcium-induced calcium releaseDRG neuronsIntracellular Ca2Cultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsRat dorsal root ganglion neuronsNeurite outgrowthDorsal root ganglion neuronsIntact intracellular Ca2Intracellular calcium mobilizationIndicator dye fluo-3Nuclear Ca2Dye Fluo-3Endoplasmic reticulum Ca2Ganglion neuronsCalcium mobilizationDependent kinase IICalcium releaseFluo-3NeuronsMammalian neuronsReticulum Ca2Elevated Ca2Elicit neurite outgrowthNuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue
Utzschneider D, Rand M, Waxman S, Kocsis J. Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue. Brain Research 1994, 635: 231-237. PMID: 8173960, DOI: 10.1016/0006-8993(94)91444-3.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsEmbryonic DRG neuronsDepolarization-induced Ca2DRG neuronsGanglion neuronsRat dorsal root ganglion neuronsAdult dorsal root ganglion neuronsCytoplasmic Ca2Sensitive fluorescent dye fluo-3Rat DRG neuronsDorsal root gangliaExcised dorsal root gangliaFluorescent dye fluo-3Postnatal time periodsElevated extracellular potassiumEarly postnatal time periodsBrief electrical stimuliNuclear Ca2Dye Fluo-3Neonatal gangliaNeonatal neuronsTarget innervationRoot gangliaAdult neuronsEmbryonic neurons
1992
Intranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron.
Birch B, Eng D, Kocsis J. Intranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 7978-7982. PMID: 1518824, PMCID: PMC49838, DOI: 10.1073/pnas.89.17.7978.Peer-Reviewed Original ResearchConceptsNeurite extensionNuclear eventsMammalian dorsal root ganglion neuronsSubcellular calcium transientsIntranuclear Ca2Confocal laser scanning microscopyGene expressionMammalian neuronsAdult mammalian neuronsCytoplasmic levelsLaser scanning microscopyNuclear Ca2Importance of Ca2Activity-dependent modulationScanning microscopyNeurite regenerationDepolarization-induced increaseCa2Transmembrane Ca2Dorsal root ganglion neuronsRegenerationExtracellular Ca2CytoplasmNucleusNeurons