1992
A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons
Pongracz F, Poolos N, Kocsis J, Shepherd G. A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. Journal Of Neurophysiology 1992, 68: 2248-2259. PMID: 1337105, PMCID: PMC2605954, DOI: 10.1152/jn.1992.68.6.2248.Peer-Reviewed Original ResearchConceptsReceptor-mediated conductanceExcitatory postsynaptic potentialsPyramidal neuronsSynaptic responsesSynaptic activationSize of EPSPsExtracellular ion concentration changesNMDA receptor-mediated activityCA1 hippocampal pyramidal cellsCA1 hippocampal pyramidal neuronsHippocampal CA1 pyramidal neuronsDendritic NMDA receptorsRepetitive synaptic activationCA1 pyramidal neuronsInhibitory synaptic responsesFrequency-dependent depressionHippocampal pyramidal neuronsNMDA receptor activationHippocampal pyramidal cellsExtracellular potassium accumulationRepetitive activityIntrinsic membrane conductancesReceptor-mediated activityHz. 4Spike afterdepolarization
1990
Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus
Poolos N, Kocsis J. Elevated extracellular potassium concentration enhances synaptic activation of N-methyl-d-aspartate receptors in hippocampus. Brain Research 1990, 508: 7-12. PMID: 2159824, DOI: 10.1016/0006-8993(90)91110-3.Peer-Reviewed Original ResearchConceptsNMDA receptor activationNMDA receptorsReceptor activationNMDA receptor-mediated componentN-methyl-D-aspartate receptorsElevated extracellular potassium concentrationReceptor-mediated componentReceptor-mediated conductanceChannel blocker tetraethylammoniumCentral nervous systemExtracellular potassium concentrationExtracellular potassium ion concentrationSlowed repolarizationOrthodromic stimulationPotassium equilibrium potentialCA1 regionPyramidal cellsRat hippocampusSynaptic activationBlocker tetraethylammoniumPostsynaptic activityRepetitive stimulationNeuronal activityNervous systemReceptors