1993
The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve
Lim J, Utzschneider D, Sakatani K, Kocsis J. The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve. Brain Research 1993, 72: 15-20. PMID: 8384095, DOI: 10.1016/0165-3806(93)90155-4.Peer-Reviewed Original ResearchConceptsOptic nerveRat optic nerveEffect of GABAMD ratsNipecotic acidGABA sensitivityGABA uptake inhibitor nipecotic acidNormal optic nervesGABAA receptor agonistOptic nerve axonsEarly postnatal periodCentral nervous system axonsThird postnatal weekSucrose gap techniqueResult of myelinationLarger GABAAxonal excitabilityControl ratsGABAA receptorsEndogenous releasePostnatal periodPostnatal weekNerve sensitivityNerveGABA
1992
Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve
Sakatani K, Black J, Kocsis J. Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve. Proceedings Of The Royal Society B 1992, 247: 155-161. PMID: 1349183, DOI: 10.1098/rspb.1992.0022.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveCentral nervous systemGABAA receptorsIntact rat optic nerveCultured glia cellsFunctional GABAA receptorsGABAA receptor agonistNeonatal optic nerveNeuronal cell bodiesO-2A progenitor cellsNon-synaptic sitesPre-myelinated axonsWhite matter regionsSynthesis of GABAAxonal excitabilityReceptor agonistEndogenous GABAGABA uptakeGlia cellsSynaptic neurotransmittersNervous systemEndogenous neurotransmittersType 2Nerve