1998
Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve
Yee J, Agulian S, Kocsis J. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy Research 1998, 29: 195-200. PMID: 9551781, DOI: 10.1016/s0920-1211(97)00086-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnticonvulsantsAstrocytesAxonsBicucullineCarrier ProteinsGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane PotentialsMembrane ProteinsMembrane Transport ProteinsModels, NeurologicalNipecotic AcidsOptic NerveOrganic Anion TransportersPotassium ChlorideProlineRatsRats, WistarReceptors, GABA-ATime FactorsVigabatrinConceptsRelease of GABAGABA levelsNipecotic acidNeonatal rat optic nerveGABA transporter inhibitorOptic nerve axonsRat optic nerveOptic nerve astrocytesEnzyme GABA transaminaseGABA transaminase activityFree GABA levelsOptic nerveAntiepileptic drugsNO-711GABA transporterNerve axonsTransaminase activityGABA transaminaseVigabatrinTransporter inhibitorsGABADepolarizationGreater releaseElevationRelease
1995
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis
Honmou O, Oyelese A, Kocsis J. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Research 1995, 692: 273-277. PMID: 8548315, DOI: 10.1016/0006-8993(95)00634-3.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsFree GABA levelsField potential analysisNipecotic acidGABA levelsPopulation excitatory postsynaptic potentialEffects of microapplicationRelease of GABAGABAA receptor activationAdult rat brainMechanism of actionGABA releasePartial seizuresAnticonvulsant gabapentinPresynaptic volleyPostsynaptic potentialsBath applicationHippocampal slicesRat brainGBP treatmentHippocampal cellsBlock uptakeGabapentinReceptor activationGABA