1996
GABA Levels in the Brain: A Target for New Antiepileptic Drugs
Kocsis J, Mattson R. GABA Levels in the Brain: A Target for New Antiepileptic Drugs. The Neuroscientist 1996, 2: 326-334. DOI: 10.1177/107385849600200610.Peer-Reviewed Original ResearchAntiepileptic drugsGABA levelsBrain GABA systemsBrain GABA levelsSeverity of seizuresNew antiepileptic drugsAbundant inhibitory neurotransmitterGABA receptor sitesNormal electrical activityMinimal side effectsPrecise cellular mechanismsAntiepileptic actionGABA releaseSeizure dischargesGABA systemPharmacological treatmentInhibitory neurotransmitterCNS neuronsEffective antiepilepticSide effectsElectrophysiological studiesMetabolic modulatorsClinical useSodium channelsDrugs
1987
Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs
Peroutka S, Mauk M, Kocsis J. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs. Neuropharmacology 1987, 26: 139-146. PMID: 2884586, DOI: 10.1016/0028-3908(87)90201-2.Peer-Reviewed Original ResearchConceptsTVX Q 7821Hippocampal slice preparationSlice preparationDose-dependent mannerMicromolar concentrationsApplication of drugsPopulation spikesRadioligand techniquesOH-DPATSchaffer collateralsHippocampal membranesNeuronal activityPyramidal layerKetanserinBaseline levelsBuspironeInitial increaseDPATSelective drugsDrugsField potentialsPhysiological effectsPopulationSimilar affinityBenzisothiazol-3